Nortin 25 mg (Capsule)

Indications

• Treatment of depression
• Treatment of nocturnal enuresis

Pharmacology

• Increases synaptic concentration of serotonin and/or norepinephrine in the CNS

Dosage & Administration

• Depression:
  • Adult: Low dose initially increased as necessary to 75-100 mg daily in divided doses or as a single dose (max. 150 mg daily)
  • Adolescent & Elderly: 30-50 mg daily in divided doses; Child not recommended for depression
• Nocturnal enuresis:
  • Child 7 years: 10 mg
  • 8-11 years: 10-20 mg
  • Over 11 years: 25-35 mg, 30 minutes before bedtime; max period of treatment (including gradual withdrawal) 3 months- full physical examination and ECG before further course.

Interaction

• Not to be given with certain medications
• Barbiturates may increase the rate of metabolism

Contraindications

• Hypersensitivity to nortriptyline
• Concomitant administration with MAOI
• Not for use during acute recovery period after myocardial infarction

Side Effects

• Dry mouth
• Sedation
• Constipation
• Increased appetite
• Blurred vision
• Tinnitus
• Euphoria
• Mania
• Rapid or irregular heartbeat

Pregnancy & Lactation

Safety not established for use in pregnancy, use only if benefits outweigh risks

Precautions & Warnings

• Not intended for treatment of bipolar depression
• Avoid abrupt withdrawal
• Risk of seizures
• Risk with certain health conditions
• Elderly and children
• Pregnancy and lactation

Overdose Effects

• Symptoms: Severe hypotension, cardiac dysrhythmias, shock, CHF, pulmonary oedema, convulsions, and CNS depression, including coma; changes in ECG
• Management: Symptomatic and supportive treatment, IV Na bicarbonate, benzodiazepines, activated charcoal, cardiac monitoring

Therapeutic Class

• Tricyclic & related anti-depressant drugs
• Tricyclic Anti-depressant

Storage Conditions

Store at 15-30°C, Protect from light and moisture

Related Brands

• Nortin 10 mg (Capsule) - navana-pharmaceuticals-ltd