Losita 5 mg (Tablet)
Unit Price: ৳ 7.00 (4 x 10: ৳ 280.00)
Strip Price: ৳ 70.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Escitalopram oxalate |
| Company | Eskayef pharmaceuticals ltd |
| Also available as |
Indications
- Treatment of major depressive episodes
- Treatment of panic disorder with or without agoraphobia
- Treatment of social anxiety disorder (social phobia)
- Treatment of generalised anxiety disorder
- Treatment of obsessive-compulsive disorder
Pharmacology
- Escitalopram is an orally administered selective serotonin reuptake inhibitor (SSRI)
- Escitalopram is the pure S-enantiomer of the racemic bicyclic phthalate derivative citalopram
- Escitalopram is at least 100 fold more potent than the R-enantiomer with respect to inhibition of 5-HT reuptake
- Escitalopram has no or very low affinity for serotonergic or other receptors including alpha- and beta-adrenergic Dopamine, Histamine, Muscarinic and benzodiazepine receptors
Dosage
- Safety of daily doses above 20 mg has not been demonstrated
- Escitalopram Oxalate is administered as a single daily dose and may be taken with or without food
- Different dosage for major depressive episodes, panic disorder, social anxiety disorder, generalised anxiety disorder, and obsessive-compulsive disorder
Administration
- Escitalopram should generally be administered once daily, morning or evening with or without food
Interaction
- SSRI or related antidepressants should not be started until 2 weeks after stopping an MAOI
- An MAOI should not be started until at least a week after an SSRI or related antidepressant has been stopped
Contraindications
- Escitalopram is contraindicated in patients with known hypersensitivity to Escitalopram or Citalopram or any of the inactive ingredients of the drug product
- Concomitant use of escitalopram in patients taking monoamine oxidase/pimozide is contraindicated
Side Effects
- Less sedating and have fewer antimuscarinic and cardiotoxic effects than tricyclic antidepressants
- Gastrointestinal effects
- Anorexia with weight loss
- Hypersensitivity reactions
- Dry mouth
- Nervousness
- Anxiety
- Headache
- Insomnia
- Tremor
- Dizziness
- Asthenia
- Hallucinations
- Drowsiness
- Convulsions
- Galactorrhoea
- Sexual dysfunction
- Urinary retention
- Sweating
- Hypomania or mania
- Movement disorders and dyskinesias
- Visual disturbances
Pregnancy & Lactation
- Escitalopram is excreted in human breast milk
- Physician should carefully consider the potential risks and benefits of treatment
Precautions & Warnings
- SSRIs should be used with caution in patients with epilepsy, cardiac disease, diabetes mellitus, angle-closure glaucoma, etc.
Use in Special Populations
- Elderly patients (>65 years of age)
- Children and adolescents (<18 years)
- Reduced renal function
- Reduced hepatic function
- Poor metabolizers of CYP2C19
- Dose adjustment in special populations
Overdose Effects
- Symptoms of overdose include CNS, gastrointestinal, cardiovascular, and electrolyte/fluid balance conditions
- There is no specific antidote
- Management includes establishing and maintaining an airway, ensuring adequate oxygenation and respiratory function, monitoring cardiac and vital signs, etc.
Therapeutic Class
- SSRIs & related anti-depressant drugs
Storage Conditions
- Store below 30°C temperature and protect from light & moisture
- Keep the medicine out of the reach of children