Nexcital 10 mg (Tablet)

Unit Price: ৳ 13.00 (3 x 10: ৳ 390.00)

Strip Price: ৳ 130.00

Medicine Details

Category	Details
Generic	Escitalopram oxalate
Company	Unimed unihealth pharmaceuticals ltd
Also available as	Nexcital 5 mg tablet

Selective serotonin reuptake inhibitor (SSRI)
Pure S-enantiomer
100 fold more potent than the R-enantiomer
No or very low affinity for serotonergic or other receptors including alpha- and beta-adrenergic dopamine, histamine, muscarinic and benzodiazepine receptors

SSRI or related antidepressants should not be started until 2 weeks after stopping an MAOI
MAOI should not be started until at least a week after an SSRI or related antidepressant has been stopped

Contraindicated in patients with known hypersensitivity to Escitalopram or Citalopram or any of the inactive ingredients of the drug product
Concomitant use of escitalopram in patients taking monoamine oxidase/pimozide is contraindicated

Less sedating and have fewer antimuscarinic and cardiotoxic effects than tricyclic antidepressants
Side-effects include gastrointestinal effects, anorexia with weight loss or increased appetite and weight gain, hypersensitivity reactions, dry mouth, nervousness, anxiety, headache, insomnia, tremor, dizziness, asthenia, hallucinations, drowsiness, convulsions, galactorrhoea, sexual dysfunction, urinary retention, sweating, hypomania or mania, movement disorders and dyskinesias, visual disturbances

Carefully consider potential risks and benefits of treatment during the third trimester
Excreted in human breast milk
Decision whether to continue or discontinue nursing or Escitalopram therapy should take into account the risk of citalopram exposure for the infant and the benefits Escitalopram treatment for the mother

Use with caution in patients with epilepsy, concurrent electroconvulsive therapy, history of mania, cardiac disease, diabetes mellitus, angle-closure glaucoma, concomitant use of drugs that increase risk of bleeding, history of bleeding disorders, hepatic and renal impairment

Initial dosage is 5 mg once daily for elderly patients (>65 years of age)
Not to be used in the treatment of children and adolescents under the age of 18 years
Dosage adjustment is not necessary in patients with mild or moderate renal impairment
Caution is advised in patients with severely reduced renal function, hepatic function, poor metabolizers of CYP2C19
Gradual reduction of dose over a period of at least one to two weeks is recommended when stopping treatment

Symptoms include dizziness, tremor, agitation, serotonin syndrome, convulsion, coma, nausea/vomiting, hypotension, tachycardia, QT interval prolongation, arrhythmia, electrolyte/fluid balance conditions
There is no specific antidote. Establish and maintain an airway, ensure adequate oxygenation and respiratory function
Gastric lavage and the use of activated charcoal should be considered
Cardiac and vital signs monitoring are recommended along with general symptomatic supportive measures
ECG monitoring is advised in case of overdose, in patients with congestive heart failure/bradyarrhythmias, in patients using concomitant medications that prolong the QT-interval, or in patients with altered metabolism, e.g. liver impairment