Nexito 5 mg (Tablet)
Medicine Details
| Category | Details |
|---|---|
| Generic | Escitalopram oxalate |
| Company | Sun pharmaceutical bangladesh ltd |
| Also available as |
Indications
- Treatment of major depressive episodes
- Treatment of panic disorder with or without agoraphobia
- Treatment of social anxiety disorder
- Treatment of generalised anxiety disorder
- Treatment of obsessive-compulsive disorder
Pharmacology
Orally administered selective serotonin reuptake inhibitor (SSRI). Pure S-enantiomer of the racemic bicyclic phthalate derivative citalopram. At least 100 fold more potent than the R-enantiomer with respect to inhibition of 5-HT reuptake. No or very low affinity for serotonergic or other receptors including alpha- and beta-adrenergic Dopamine, Histamine, Muscarinic and benzodiazepine receptors.
Dosage
Max daily dose is 20 mg. Usual dosage for different indications varies from 5 mg to 20 mg once daily.
Administration
Generally administered once daily, morning or evening with or without food.
Interaction
SSRI or related antidepressants should not be started until 2 weeks after stopping an MAOI. Conversely, an MAOI should not be started until at least a week after an SSRI or related antidepressant has been stopped (2 weeks in the case of paroxetine and sertraline, at least 5 weeks in the case of fluoxetine).
Contraindications
- Known hypersensitivity to Escitalopram or Citalopram or any of the inactive ingredients of the drug product
- Concomitant use of escitalopram in patients taking monoamine oxidase/pimozide
Side Effects
- Less sedating and have fewer antimuscarinic and cardiotoxic effects than tricyclic antidepressants
- Gastrointestinal effects, anorexia with weight loss or increased appetite and weight gain
- Hypersensitivity reactions including rash, urticaria, angioedema, anaphylaxis, arthralgia, myalgia, and photosensitivity
- Dry mouth, nervousness, anxiety, headache, insomnia, tremor, dizziness, asthenia, hallucinations, drowsiness, convulsions, galactorrhoea, sexual dysfunction, urinary retention, sweating, hypomania or mania, movement disorders and dyskinesias, visual disturbances
Pregnancy & Lactation
Excreted in human breast milk. The decision whether to continue or discontinue either nursing or Escitalopram therapy should take into account the risk of citalopram exposure for the infant and the benefits Escitalopram treatment for the mother.
Precautions & Warnings
- Use with caution in patients with epilepsy, history of mania, cardiac disease, diabetes mellitus, angle-closure glaucoma, concomitant use of drugs that increase risk of bleeding, history of bleeding disorders, hepatic and renal impairment.
Use in Special Populations
- Elderly patients (>65 years of age) - Initial dosage is 5 mg once daily, may be increased to 10 mg daily
- Children and adolescents (<18 years): Not recommended
- Reduced renal function - Caution is advised in patients with severely reduced renal function
- Reduced hepatic function - Caution and extra careful dose titration is advised
- Poor metabolizers of CYP2C19 - Initial dose of 5 mg daily for the first two weeks of treatment is recommended
Overdose Effects
- Symptoms mainly related to the central nervous system, gastrointestinal system, and the cardiovascular system
- No specific antidote. General symptomatic supportive measures are recommended
Therapeutic Class
SSRIs & related anti-depressant drugs
Storage Conditions
Store below 30°C temperature and protect from light & moisture. Keep the medicine out of the reach of children.