Acipam 10 mg (Tablet)

Unit Price: ৳ 10.00 (3 x 10: ৳ 300.00)
Strip Price: ৳ 100.00

Medicine Details

Category Details
Generic Escitalopram oxalate
Company Ibn sina pharmaceuticals ltd
Also available as
Acipam 5 mg tablet

Indications

  • Treatment of major depressive episodes
  • Treatment of panic disorder with or without agoraphobia
  • Treatment of social anxiety disorder (social phobia)
  • Treatment of generalised anxiety disorder
  • Treatment of obsessive-compulsive disorder

Pharmacology

  • Selective serotonin reuptake inhibitor (SSRI)
  • Pure S-enantiomer of racemic bicyclic phthalate derivative citalopram
  • At least 100 fold more potent than the R-enantiomer in inhibiting 5-HT reuptake
  • Low affinity for serotonergic or other receptors including alpha- and beta-adrenergic Dopamine, Histamine, Muscarinic and benzodiazepine receptors

Dosage

  • Usual dosage is 10 mg once daily for major depressive episodes
  • Initial dose of 5 mg recommended for panic disorder with or without agoraphobia
  • Usual dosage is 10 mg once daily for social anxiety disorder
  • Initial dosage is 10 mg once daily for generalised anxiety disorder
  • Initial dosage is 10 mg once daily for obsessive-compulsive disorder

Administration

  • Administered once daily, morning or evening with or without food

Interaction

  • SSRI or related antidepressants should not be started until 2 weeks after stopping an MAOI
  • An MAOI should not be started until at least a week after an SSRI or related antidepressant has been stopped

Contraindications

  • Contraindicated in patients with known hypersensitivity to Escitalopram or Citalopram or any of the inactive ingredients of the drug product
  • Concomitant use of escitalopram in patients taking monoamine oxidase/pimozide is contraindicated

Side Effects

  • Less sedating and have fewer antimuscarinic and cardiotoxic effects than tricyclic antidepressants
  • Common side-effects include nausea, vomiting, dyspepsia, abdominal pain, diarrhoea, constipation, anorexia with weight loss, hypersensitivity reactions, dry mouth, nervousness, anxiety, headache, insomnia, tremor, dizziness
  • Other side-effects include asthenia, hallucinations, drowsiness, convulsions, sexual dysfunction, urinary retention, sweating, hypomania or mania, movement disorders, dyskinesias, visual disturbances

Pregnancy & Lactation

  • Consider potential risks and benefits of treatment when treating a pregnant woman with Escitalopram during the third trimester
  • Excreted in human breast milk, weigh risk of exposure for the infant and benefits of treatment for the mother

Precautions & Warnings

  • Use with caution in patients with epilepsy, cardiac disease, diabetes mellitus, angle-closure glaucoma, history of mania, concurrent electroconvulsive therapy, hepatic and renal impairment
  • Avoid use if poorly controlled epilepsy, discontinue if convulsions develop

Use in Special Populations

  • Elderly patients (>65 years of age): Initial dosage is 5 mg once daily
  • Use not recommended in children and adolescents (<18 years)
  • Dosage adjustment not necessary in patients with mild or moderate renal impairment
  • Caution advised in patients with severely reduced renal function, and hepatic function
  • Initial dose of 5 mg daily for the first two weeks recommended in patients with mild or moderate hepatic impairment
  • For patients known to be poor metabolisers with respect to CYP2C19, an initial dose of 5 mg daily during the first two weeks of treatment is recommended

Overdose Effects

  • Symptoms may include dizziness, tremor, agitation, serotonin syndrome, convulsion, coma, nausea/vomiting, hypotension, tachycardia, QT interval prolongation, arrhythmia, electrolyte/fluid balance conditions
  • No specific antidote, general symptomatic supportive measures recommended

Therapeutic Class

  • SSRIs & related anti-depressant drugs

Storage Conditions

  • Store below 30°C temperature and protect from light & moisture
  • Keep the medicine out of the reach of children

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