Talopram 5 mg (Tablet)

Unit Price: ৳ 5.30 (3 x 10: ৳ 159.00)

Strip Price: ৳ 53.00

Medicine Details

Orally administered selective serotonin reuptake inhibitor (SSRI)
Pure S-enantiomer of racemic bicyclic phthalate derivative citalopram
At least 100 fold more potent than the R-enantiomer with respect to inhibition of 5-HT reuptake
No or very low affinity for serotonergic or other receptors including alpha- and beta-adrenergic, Dopamine, Histamine, Muscarinic, and benzodiazepine receptors

Usual dosage is 10 mg once daily for major depressive episodes
Initial dose of 5 mg is recommended for the first week before increasing to 10 mg daily for panic disorder
Usual dosage is 10 mg once daily for social anxiety disorder
Initial dosage is 10 mg once daily for generalized anxiety disorder
Initial dosage is 10 mg once daily for obsessive-compulsive disorder

SSRI or related antidepressants should not be started until 2 weeks after stopping an MAOI
An MAOI should not be started until at least a week after an SSRI or related antidepressant has been stopped (2 weeks in the case of paroxetine and sertraline, at least 5 weeks in the case of fluoxetine)

Contraindicated in patients with known hypersensitivity to Escitalopram or Citalopram or any of the inactive ingredients of the drug product
Concomitant use of escitalopram in patients taking monoamine oxidase/pimozide is contraindicated

Less sedating and have fewer antimuscarinic and cardiotoxic effects than tricyclic antidepressants
Common side effects include nausea, vomiting, dyspepsia, abdominal pain, diarrhea, constipation, anorexia with weight loss, hypersensitivity reactions including rash, urticaria, angioedema, anaphylaxis, dry mouth, nervousness, anxiety, etc.

Physician should carefully consider the potential risks and benefits of treatment when treating a pregnant woman with Escitalopram during the third trimester
Excreted in human breast milk, decision on whether to continue or discontinue nursing or Escitalopram therapy should take into account the risk of citalopram exposure for the infant and the benefits of Escitalopram treatment for the mother

Use with caution in patients with epilepsy, concurrent electroconvulsive therapy, history of mania, cardiac disease, diabetes mellitus, angle-closure glaucoma, concomitant use of drugs that increase risk of bleeding, history of bleeding disorders, hepatic and renal impairment

Initial dosage is 5 mg once daily for elderly patients (>65 years of age)
Escitalopram should not be used in the treatment of children and adolescents under the age of 18 years
Dosage adjustment is not necessary in patients with mild or moderate renal impairment
An initial dose of 5 mg daily for the first two weeks of treatment is recommended in patients with mild or moderate hepatic impairment
For patients who are known to be poor metabolisers with respect to CYP2C19, an initial dose of 5 mg daily during the first two weeks of treatment is recommended

Symptoms include dizziness, tremor, agitation, serotonin syndrome, convulsion, coma, nausea, vomiting, hypotension, tachycardia, QT interval prolongation, arrhythmia, hypokalaemia, hyponatremia
No specific antidote, general symptomatic supportive measures recommended, ECG monitoring advised