Talopram 10 mg (Tablet)
Medicine Details
| Category | Details |
|---|---|
| Generic | Escitalopram oxalate |
| Company | Navana pharmaceuticals ltd |
| Also available as |
Indications
- Treatment of major depressive episodes
- Treatment of panic disorder with or without agoraphobia
- Treatment of social anxiety disorder (social phobia)
- Treatment of generalised anxiety disorder
- Treatment of obsessive-compulsive disorder
Pharmacology
- Selective serotonin reuptake inhibitor (SSRI)
- Pure S-enantiomer of the racemic bicyclic phthalate derivative citalopram
- 100 fold more potent than the R-enantiomer with respect to inhibition of 5-HT reuptake
- No or very low affinity for serotonergic or other receptors including alpha- and beta-adrenergic, Dopamine, Histamine, Muscarinic, and benzodiazepine receptors
Dosage
- Usual dosage is 10 mg once daily for major depressive episodes
- Initial dose of 5 mg recommended for panic disorder with or without agoraphobia
- Usual dosage is 10 mg once daily for social anxiety disorder
- Initial dosage is 10 mg once daily for generalised anxiety disorder
- Initial dosage is 10 mg once daily for obsessive-compulsive disorder
Administration
Generally administered once daily, morning or evening with or without food
Interaction
SSRI or related antidepressants should not be started until 2 weeks after stopping an MAOI
Contraindications
Contraindicated in patients with known hypersensitivity to Escitalopram or Citalopram or any of the inactive ingredients of the drug product
Side Effects
- Gastrointestinal effects like nausea, vomiting, dyspepsia, abdominal pain, diarrhoea, constipation
- Anorexia with weight loss
- Hypersensitivity reactions including rash, urticaria, angioedema, anaphylaxis
- Dry mouth, nervousness, anxiety, headache, insomnia, tremor
- Dizziness, asthenia, hallucinations, drowsiness, convulsions
- Galactorrhoea, sexual dysfunction, urinary retention, sweating, hypomania or mania, movement disorders, visual disturbances
Pregnancy & Lactation
Excreted in human breast milk. The decision whether to continue or discontinue nursing or Escitalopram therapy should take into account the risk of citalopram exposure for the infant and the benefits of Escitalopram treatment for the mother
Precautions & Warnings
SSRIs should be used with caution in patients with epilepsy, cardiac disease, diabetes mellitus, angle-closure glaucoma, hepatic and renal impairment
Use in Special Populations
- Initial dosage is 5 mg once daily for elderly patients
- Escitalopram should not be used in the treatment of children and adolescents under the age of 18 years
- Dosage adjustment is not necessary in patients with mild or moderate renal impairment
- Caution is advised in patients with severely reduced renal function, reduced hepatic function, poor metabolizers of CYP2C19
Overdose Effects
- Symptoms mainly related to the central nervous system, the gastrointestinal system, and the cardiovascular system
- No specific antidote. Establish and maintain an airway, ensure adequate oxygenation and respiratory function. Gastric lavage and the use of activated charcoal should be considered
Therapeutic Class
SSRIs & related anti-depressant drugs
Storage Conditions
Store below 30°C temperature and protect from light & moisture. Keep the medicine out of the reach of children