Diliner DR 60 mg (Capsule (Delayed Release))

Unit Price: ৳ 16.11 (3 x 6: ৳ 289.98)
Strip Price: ৳ 96.66

Medicine Details

Category Details
Generic Duloxetine hydrochloride
Company Square pharmaceuticals plc
Also available as
Diliner dr 20 mg dr capsule

Title

  • Diliner DR

Categories

  • Serotonin-Norepinephrine Reuptake Inhibitor (SNRI)

Description

  • Selective Serotonin and Norepinephrine Reuptake Inhibitor (SSNRI)
  • Oral Administration
  • Less Potent Inhibitor of Dopamine Reuptake
  • No Significant Affinity for Various Receptors
  • Well Absorbed
  • Mainly Metabolized by the Liver
  • CYP1A2 and CYP2D6 Isozymes Responsible for Metabolism
  • Contraindicated in Patients with Known Hypersensitivity
  • Not Approved for Bipolar Depression Treatment
  • Not Recommended for Patients with Substantial Alcohol Use or Chronic Liver Disease
  • Use Cautiously in Patients with Controlled Narrow-Angle Glaucoma
  • Adverse Events: Nausea, Dizziness, Dry Mouth, Constipation, Decreased Appetite, Fatigue, Somnolence, Increased Sweating, Hyperhidrosis, Asthenia
  • May Slightly Increase Blood Pressure
  • Pregnancy Category C
  • Unknown Excretion into Human Milk
  • Not Recommended for Nursing Mothers
  • Monitoring Required for Clinical Worsening, Suicidality, and Unusual Behavior
  • Blood Pressure Monitoring
  • Cautioned about Risk of Bleeding with NSAIDs, Aspirin, or Coagulation-Affecting Drugs
  • Use with Care in Patients with History of Mania
  • Use with Care in Patients with History of Seizure Disorder
  • Safety and Efficacy Not Established in Pediatric Patients
  • Limited Clinical Experience with Overdose
  • No Specific Antidote Available
  • Storage: Do not store above 30°C, Keep away from light, Keep out of the reach of children

Indications

  • Major Depressive Disorder (MDD)
  • Generalized Anxiety Disorder (GAD)
  • Diabetic Peripheral Neuropathic Pain (DPNP)
  • Fibromyalgia
  • Chronic Musculoskeletal Pain

Pharmacology

  • Serotonin and Norepinephrine Reuptake Inhibitor (SNRI)
  • Selective Serotonin and Norepinephrine Reuptake Inhibitor (SSNRI)
  • Less Potent Inhibitor of Dopamine Reuptake
  • No Significant Affinity for Various Receptors
  • Mainly Metabolized by the Liver

Dosage & Administration

  • MDD Starting Dose: 40 mg/day to 60 mg/day
  • MDD Target Dose: Acute - 40 mg/day to 60 mg/day; Maintenance - 60 mg/day
  • MDD Maximum Dose: 120 mg/day
  • GAD Starting Dose: 60 mg/day
  • GAD Target Dose: 60 mg/day
  • GAD Maximum Dose: 120 mg/day
  • DPNP Starting Dose: 60 mg/day
  • DPNP Target Dose: 60 mg/day
  • DPNP Maximum Dose: 60 mg/day
  • Fibromyalgia Starting Dose: 30 mg/day
  • Fibromyalgia Target Dose: 60 mg/day
  • Fibromyalgia Maximum Dose: 60 mg/day
  • Chronic Musculoskeletal Pain Starting Dose: 30 mg/day
  • Chronic Musculoskeletal Pain Target Dose: 60 mg/day
  • Chronic Musculoskeletal Pain Maximum Dose: 60 mg/day

Interaction

  • Metabolism by CYP1A2 and CYP2D6 Isozymes
  • Coadministration with Fluvoxamine Increased AUC, Cmax, and t
  • Other Drugs Inhibiting CYP1A2 Metabolism Include Cimetidine, Ciprofloxacin, Enoxacin
  • Concomitant Use with Potent Inhibitors of CYP2D6 May Increase Concentrations

Contraindications

  • Known Hypersensitivity
  • Not Approved for Bipolar Depression
  • Not Recommended for Patients with Substantial Alcohol Use or Chronic Liver Disease
  • Use Cautiously in Patients with Controlled Narrow-Angle Glaucoma

Side Effects

  • Nausea
  • Dizziness
  • Dry Mouth
  • Constipation
  • Decreased Appetite
  • Fatigue
  • Somnolence
  • Increased Sweating
  • Hyperhidrosis
  • Asthenia
  • Slight Increase in Blood Pressure

Pregnancy & Lactation

  • Pregnancy Category C
  • Use Only if Potential Benefit Justifies Potential Risk
  • Effect on Labor and Delivery Unknown
  • Not Recommended for Nursing Mothers

Precautions & Warnings

  • Monitoring Required for Clinical Worsening, Suicidality, and Unusual Behavior
  • Blood Pressure Monitoring
  • Cautioned about Risk of Bleeding with NSAIDs, Aspirin, or Coagulation-Affecting Drugs
  • Use with Care in Patients with History of Mania
  • Use with Care in Patients with History of Seizure Disorder

Use in Special Populations

  • Safety and Efficacy Not Established in Pediatric Patients

Overdose Effects

  • Limited Clinical Experience with Overdose
  • No Specific Antidote Available

Therapeutic Class

  • Serotonin-Norepinephrine Reuptake Inhibitor (SNRI)

Storage Conditions

  • Do not store above 30°C
  • Keep away from light
  • Keep out of the reach of children

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