Duloxen 30 mg (Tablet (Delayed Release))

Unit Price: ৳ 12.00 (3 x 10: ৳ 360.00)

Strip Price: ৳ 120.00

Medicine Details

Category	Details
Generic	Duloxetine hydrochloride
Company	Incepta pharmaceuticals ltd
Also available as	Duloxen 20 mg tablet Duloxen 60 mg tablet

Indications

Major Depressive Disorder (MDD)
Generalized Anxiety Disorder (GAD)
Diabetic Peripheral Neuropathic Pain (DPNP)
Fibromyalgia
Chronic Musculoskeletal Pain

Pharmacology

Selective serotonin and norepinephrine reuptake inhibitor (SSNRI) for oral administration

Dosage & Administration

Starting Dose: 30-60 mg/day
Target Dose: 30-120 mg/day
Maximum Dose: 120 mg/day

Metabolism Interaction

Inhibited by CYP1A2 and CYP2D6 isozymes
Co-administration with fluvoxamine increases AUC, Cmax and t

Contraindications

Known hypersensitivity to drug or inactive ingredients
Not approved for bipolar depression
Patients with substantial alcohol use or chronic liver disease
Cautious use in patients with controlled narrow-angle glaucoma

Side Effects

Nausea
Dizziness
Dry mouth
Constipation
Decreased appetite
Fatigue
Somnolence
Increased sweating
Hyperhidrosis
Asthenia

Pregnancy & Lactation

Pregnancy Category C: Should be used during pregnancy if benefit justifies the risk, not recommended during lactation

Precautions & Warnings

Monitoring for clinical worsening and suicidality
Blood pressure measurement prior to treatment and periodically thereafter
Caution about risk of bleeding with concomitant use of Duloxen and NSAIDs or other coagulation-affecting drugs
Prescribed with care in patients with a history of mania or seizure disorder

Use in Special Populations

Safety and efficacy in pediatric patients not established

Overdose Effects

Limited clinical experience; no specific antidote; general measures for overdose management

Therapeutic Class

Serotonin-norepinephrine reuptake inhibitor (SNRI)

Storage Conditions

Do not store above 30°C; Keep away from light and out of reach of children

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