Duzela 20 mg (Capsule (Delayed Release))

Unit Price: ৳ 8.00 (5 x 10: ৳ 400.00)
Strip Price: ৳ 80.00

Medicine Details

Category Details
Generic Duloxetine hydrochloride
Company Sun pharmaceutical bangladesh ltd

Indications

  • Major Depressive Disorder (MDD)
  • Generalized Anxiety Disorder (GAD)
  • Diabetic Peripheral Neuropathic Pain (DPNP)
  • Fibromyalgia
  • Chronic Musculoskeletal Pain

Pharmacology

Serotonin and norepinephrine reuptake inhibitor (SNRI) for oral administration. Less potent inhibitor of dopamine reuptake. No significant affinity for various receptors in vitro. Well absorbed. Mainly eliminated through hepatic metabolism.

Dosage & Administration

  • Major Depressive Disorder (MDD):
    • Starting Dose:
      • 40 mg/day to 60 mg/day
    • Target Dose:
      • Acute: 40 mg/day (20 mg twice daily) to 60 mg/day (once daily or as 30 mg twice daily)
      • Maintenance: 60 mg/day
    • Maximum Dose:
      • 120 mg/day
  • Generalized Anxiety Disorder (GAD):
    • Starting Dose:
      • 60 mg/day
    • Target Dose:
      • 60 mg/day (once daily)
    • Maximum Dose:
      • 120 mg/day
  • Diabetic Peripheral Neuropathic Pain (DPNP):
    • Starting Dose:
      • 60 mg/day
    • Target Dose:
      • 60 mg/day (once daily)
    • Maximum Dose:
      • 60 mg/day
  • Fibromyalgia:
    • Starting Dose:
      • 30 mg/day
    • Target Dose:
      • 60 mg/day (once daily)
    • Maximum Dose:
      • 60 mg/day
  • Chronic Musculoskeletal Pain:
    • Starting Dose:
      • 30 mg/day
    • Target Dose:
      • 60 mg/day (once daily)
    • Maximum Dose:
      • 60 mg/day

Interaction

Metabolism affected by CYP1A2 and CYP2D6 isozymes. Co-administration with inhibitors may increase drug concentrations.

Contraindications

  • Known hypersensitivity to the drug or its inactive ingredients
  • Not approved for treating bipolar depression
  • Not for patients with substantial alcohol use or chronic liver disease
  • Use cautiously in patients with controlled narrow-angle glaucoma

Side Effects

  • Nausea
  • Dizziness
  • Dry mouth
  • Constipation
  • Decreased appetite
  • Fatigue
  • Somnolence
  • Increased sweating
  • Hyperhidrosis
  • Asthenia
  • Slight increase in blood pressure

Pregnancy & Lactation

  • Pregnancy: Category C. Use only if potential benefit justifies potential risk to the fetus.
  • Labor and Delivery: Effects unknown. Use only if potential benefit justifies potential risk to the fetus.
  • Lactation: Not recommended

Precautions & Warnings

  • Monitor patients for clinical worsening, suicidality, and unusual behavior
  • Measure blood pressure prior to treatment and periodically
  • Caution about risk of bleeding with concomitant use of Duzela and NSAIDs/other coagulation-affecting drugs
  • Use cautiously in patients with history of mania/seizure disorder

Use in Special Populations

  • Safety and efficacy in pediatric patients not established

Overdose Effects

Limited clinical experience. No specific antidote. General overdose management measures may be employed.

Therapeutic Class

Serotonin-norepinephrine reuptake inhibitor (SNRI)

Storage Conditions

Do not store above 30°C. Keep away from light and out of the reach of children.

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