Xinolax DR 20 mg (Capsule (Delayed Release))

Unit Price: ৳ 8.00 (3 x 10: ৳ 240.00)

Strip Price: ৳ 80.00

Medicine Details

Category	Details
Generic	Duloxetine hydrochloride
Company	Opsonin pharma ltd
Also available as	Xinolax dr 30 mg dr capsule Xinolax dr 60 mg dr capsule

Indications

Major Depressive Disorder (MDD)
Generalized Anxiety Disorder (GAD)
Diabetic Peripheral Neuropathic Pain (DPNP)
Fibromyalgia
Chronic Musculoskeletal Pain

Pharmacology

Selective serotonin and norepinephrine reuptake inhibitor (SSNRI) for oral administration. Less potent inhibitor of dopamine reuptake. No significant affinity for various receptors. Does not inhibit monoamine oxidase. Well absorbed. Mainly hepatic metabolism.

Dosage & Administration

Major Depressive Disorder (MDD):
- Starting Dose: 40 mg/day to 60 mg/day
- Target Dose: Acute: 40 mg/day (20 mg twice daily) to 60 mg/day (once daily or as 30 mg twice daily); Maintenance: 60 mg/day
- Maximum Dose: 120 mg/day
Generalized Anxiety Disorder (GAD):
- Starting Dose: 60 mg/day
- Target Dose: 60 mg/day (once daily)
- Maximum Dose: 120 mg/day
Diabetic Peripheral Neuropathic Pain (DPNP):
- Starting Dose: 60 mg/day
- Target Dose: 60 mg/day (once daily)
- Maximum Dose: 60 mg/day
Fibromyalgia:
- Starting Dose: 30 mg/day
- Target Dose: 60 mg/day (once daily)
- Maximum Dose: 60 mg/day
Chronic Musculoskeletal Pain:
- Starting Dose: 30 mg/day
- Target Dose: 60 mg/day (once daily)
- Maximum Dose: 60 mg/day

Interaction

Metabolism involves CYP1A2 and CYP2D6 isozymes. Co-administration with inhibitors of CYP1A2 or CYP2D6 should be avoided.

Contraindications

Known Hypersensitivity: Contraindicated
Bipolar Depression: Not approved for use
Substantial Alcohol Use or Chronic Liver Disease: Not recommended
Controlled Narrow-angle Glaucoma: Use cautiously

Side Effects

Nausea
Dizziness
Dry Mouth
Constipation
Decreased Appetite
Fatigue
Somnolence
Increased Sweating
Hyperhidrosis
Asthenia
Slightly increased blood pressure

Pregnancy & Lactation

Pregnancy Category: Category C
Lactation: Not recommended

Precautions & Warnings

Monitoring: Appropriate monitoring for clinical worsening, suicidality, and unusual changes in behavior
Blood Pressure: Measured prior to treatment and periodically throughout
Risk of Bleeding: Cautioned about concomitant use with drugs affecting coagulation
History of Mania or Seizure Disorder: Prescribed with care

Use in Special Populations

Pediatric Population: Safety and efficacy not established

Overdose Effects

Limited clinical experience. No specific antidote. General measures employed in overdose management. Activated charcoal may be useful in limiting absorption.

Therapeutic Class

Serotonin-norepinephrine reuptake inhibitor (SNRI)

Storage Conditions

Do not store above 30°C. Keep away from light and out of the reach of children.