Xinolax DR 20 mg (Capsule (Delayed Release))

Unit Price: ৳ 8.00 (3 x 10: ৳ 240.00)
Strip Price: ৳ 80.00

Medicine Details

Category Details
Generic Duloxetine hydrochloride
Company Opsonin pharma ltd
Also available as
Xinolax dr 30 mg dr capsule Xinolax dr 60 mg dr capsule

Indications

  • Major Depressive Disorder (MDD)
  • Generalized Anxiety Disorder (GAD)
  • Diabetic Peripheral Neuropathic Pain (DPNP)
  • Fibromyalgia
  • Chronic Musculoskeletal Pain

Pharmacology

Selective serotonin and norepinephrine reuptake inhibitor (SSNRI) for oral administration. Less potent inhibitor of dopamine reuptake. No significant affinity for various receptors. Does not inhibit monoamine oxidase. Well absorbed. Mainly hepatic metabolism.

Dosage & Administration

  • Major Depressive Disorder (MDD):
    • Starting Dose: 40 mg/day to 60 mg/day
    • Target Dose: Acute: 40 mg/day (20 mg twice daily) to 60 mg/day (once daily or as 30 mg twice daily); Maintenance: 60 mg/day
    • Maximum Dose: 120 mg/day
  • Generalized Anxiety Disorder (GAD):
    • Starting Dose: 60 mg/day
    • Target Dose: 60 mg/day (once daily)
    • Maximum Dose: 120 mg/day
  • Diabetic Peripheral Neuropathic Pain (DPNP):
    • Starting Dose: 60 mg/day
    • Target Dose: 60 mg/day (once daily)
    • Maximum Dose: 60 mg/day
  • Fibromyalgia:
    • Starting Dose: 30 mg/day
    • Target Dose: 60 mg/day (once daily)
    • Maximum Dose: 60 mg/day
  • Chronic Musculoskeletal Pain:
    • Starting Dose: 30 mg/day
    • Target Dose: 60 mg/day (once daily)
    • Maximum Dose: 60 mg/day

Interaction

Metabolism involves CYP1A2 and CYP2D6 isozymes. Co-administration with inhibitors of CYP1A2 or CYP2D6 should be avoided.

Contraindications

  • Known Hypersensitivity: Contraindicated
  • Bipolar Depression: Not approved for use
  • Substantial Alcohol Use or Chronic Liver Disease: Not recommended
  • Controlled Narrow-angle Glaucoma: Use cautiously

Side Effects

  • Nausea
  • Dizziness
  • Dry Mouth
  • Constipation
  • Decreased Appetite
  • Fatigue
  • Somnolence
  • Increased Sweating
  • Hyperhidrosis
  • Asthenia
  • Slightly increased blood pressure

Pregnancy & Lactation

  • Pregnancy Category: Category C
  • Lactation: Not recommended

Precautions & Warnings

  • Monitoring: Appropriate monitoring for clinical worsening, suicidality, and unusual changes in behavior
  • Blood Pressure: Measured prior to treatment and periodically throughout
  • Risk of Bleeding: Cautioned about concomitant use with drugs affecting coagulation
  • History of Mania or Seizure Disorder: Prescribed with care

Use in Special Populations

  • Pediatric Population: Safety and efficacy not established

Overdose Effects

Limited clinical experience. No specific antidote. General measures employed in overdose management. Activated charcoal may be useful in limiting absorption.

Therapeutic Class

Serotonin-norepinephrine reuptake inhibitor (SNRI)

Storage Conditions

Do not store above 30°C. Keep away from light and out of the reach of children.

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