Xinolax DR 30 mg (Capsule (Delayed Release))

Unit Price: ৳ 10.00 (2 x 10: ৳ 200.00)
Strip Price: ৳ 100.00

Medicine Details

Category Details
Generic Duloxetine hydrochloride
Company Opsonin pharma ltd
Also available as
Xinolax dr 20 mg dr capsule Xinolax dr 60 mg dr capsule

Title

    Categories

    • Serotonin-norepinephrine reuptake inhibitor (SNRI)

    Description

      Dimensions

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          Functions

          • Treatment of Major Depressive Disorder (MDD)
          • Treatment of Generalized Anxiety Disorder (GAD)
          • Treatment of Diabetic Peripheral Neuropathic Pain (DPNP)
          • Treatment of Fibromyalgia
          • Treatment of Chronic Musculoskeletal Pain

          Materials

            Technical Specifications

            • Duloxetine Hydrochloride as active ingredient
            • Selective serotonin and norepinephrine reuptake inhibitor (SSNRI)
            • Inhibits dopamine reuptake
            • No significant affinity for various receptors
            • Well absorbed when orally administered
            • Metabolized mainly through hepatic metabolism

            Design Elements

              Usability Features

                Dosage

                • Starting Dose for MDD: 40 mg/day to 60 mg/day
                • Target Dose for MDD: Acute - 40 mg/day to 60 mg/day; Maintenance - 60 mg/day
                • Maximum Dose for MDD: 120 mg/day
                • Starting Dose for GAD: 60 mg/day
                • Target Dose for GAD: 60 mg/day
                • Maximum Dose for GAD: 120 mg/day
                • Starting Dose for DPNP: 60 mg/day
                • Target Dose for DPNP: 60 mg/day
                • Maximum Dose for DPNP: 60 mg/day
                • Starting Dose for Fibromyalgia: 30 mg/day
                • Target Dose for Fibromyalgia: 60 mg/day
                • Maximum Dose for Fibromyalgia: 60 mg/day
                • Starting Dose for Chronic Musculoskeletal Pain: 30 mg/day
                • Target Dose for Chronic Musculoskeletal Pain: 60 mg/day
                • Maximum Dose for Chronic Musculoskeletal Pain: 60 mg/day
                • Some patients may benefit from starting at 30 mg once daily
                • No evidence that doses greater than 60 mg/day confers an additional benefit
                • Gradual dose reduction is recommended to avoid discontinuation symptoms

                Interaction

                • Metabolism affected by CYP1A2 and CYP2D6 isozymes
                • Inhibited by fluvoxamine, cimetidine, and quinolone antimicrobials
                • Concomitant use with potent CYP2D6 inhibitors may increase concentrations

                Contraindications

                • Known hypersensitivity to Duloxetine or inactive ingredients
                • Not approved for treating bipolar depression
                • Not for patients with substantial alcohol use or chronic liver disease
                • Use cautiously in patients with controlled narrow-angle glaucoma

                Side Effects

                • Nausea
                • Dizziness
                • Dry mouth
                • Constipation
                • Decreased appetite
                • Fatigue
                • Somnolence
                • Increased sweating
                • Hyperhidrosis
                • Asthenia
                • Slightly increases blood pressure
                • No clinically significant differences observed for cardiac intervals

                Pregnancy & Lactation

                • Pregnancy Category C
                • Use during pregnancy only if benefit justifies potential risk to fetus
                • Effect on labor and delivery in humans is unknown
                • Use during labor and delivery only if benefit justifies potential risk to fetus
                • Unknown whether excreted into human milk, not recommended for nursing

                Precautions & Warnings

                • Patients treated with antidepressants should be monitored for clinical worsening and suicidality
                • Blood pressure should be measured before and during treatment
                • Caution about bleeding risk with concomitant use of NSAIDs, aspirin, or other coagulation-affecting drugs
                • Use cautiously in patients with a history of mania or seizure disorder

                Use in Special Populations

                • Safety and efficacy in pediatric patients not established

                Overdose Effects

                • Limited clinical experience with overdose in humans
                • No specific antidote
                • Treatment should consist of general measures for overdose management
                • Emesis induction not recommended
                • Gastric lavage with appropriate airway protection may be indicated if performed soon after ingestion or in symptomatic patients
                • Activated charcoal may be useful in limiting absorption

                Storage Conditions

                • Do not store above 30°C
                • Keep away from light and out of the reach of children

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