Relafin 50 mg (Tablet)

Unit Price: ৳ 15.11 (3 x 10: ৳ 453.30)
Strip Price: ৳ 151.10

Medicine Details

Category Details
Generic Fluvoxamine maleate
Company General pharmaceuticals ltd
Also available as
Relafin 100 mg tablet

Indications

  • Obsessive-Compulsive Disorder
  • Depressive illness
  • Panic Disorder
  • Eating Disorders
  • Chronic Tension Headache

Pharmacology

  • Inhibition of CNS neuronal uptake of serotonin
  • Blocking the reuptake of serotonin at the serotonin reuptake pump
  • Enhancing the actions of serotonin on 5HT1A autoreceptors
  • Virtually no affinity for α1- or α2-adrenergic, β-adrenergic, muscarinic, dopamine D2, histamine H1, GABA-benzodiazepine, opiate, 5-HT1, or 5-HT2 receptors
  • Affinity for binding to σ1 receptors

Dosage & Administration

  • Recommended starting dose for adults: 50 mg
  • Recommended starting dose for pediatric populations (ages 8-17 years): 25 mg
  • Maximum therapeutic benefit not to exceed 300 mg per day for adults
  • Maximum dose in children up to age 11 should not exceed 200 mg/day
  • Elderly patients and those with hepatic impairment have decreased clearance of fluvoxamine maleate

Interactions

  • Inhibits several cytochrome P450 isoenzymes (CYP1A2, CYP2C9, CYP3A4, and CYP2C19)
  • Elevated carbamazepine levels and symptoms of toxicity with coadministration
  • Rare postmarketing reports of weakness, hyperreflexia, and incoordination following use of an SSRI and sumatriptan
  • Coadministration with tacrine increased tacrine C max and AUC five- and eight-fold
  • Significantly increased plasma TCA levels with tricyclic antidepressants (TCAs)
  • Severe vomiting with coadministration of tryptophan

Contraindications

  • Coadministration of tizanidine, thioridazine, alosetron, pimozide
  • Serotonin Syndrome and MAOIs
  • Not to use MAOIs intended to treat psychiatric disorders with Fluvoxamine Maleate Tablets or within 14 days of stopping treatment

Side Effects

  • Most common reactions in controlled trials include nausea, somnolence, insomnia, asthenia, nervousness
  • Additional events include anorgasmia, decreased libido, dry mouth, and urinary frequency

Pregnancy & Lactation

  • Consider both potential risks and benefits when treating a pregnant woman
  • Fluvoxamine is secreted in human breast milk

Precautions & Warnings

  • Use with caution in patients with a history of mania, seizures, suicide, concomitant ECT, cardiac disease, diabetes mellitus, angle-closure glaucoma, history of bleeding disorders
  • May impair the performance of skilled tasks (driving)

Therapeutic Class

  • SSRIs & related anti-depressant drugs

Storage Conditions

  • Keep below 30°C temperature, away from light & moisture, Keep out of the reach of children

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