Oxat 20 mg (Tablet)

Indications

• Major Depressive Disorder
• Obsessive Compulsive Disorder
• Panic Disorder
• Social Anxiety Disorder
• Generalized Anxiety Disorder
• Posttraumatic Stress Disorder

Pharmacological Action

• Potentiation of serotonergic activity
• Inhibition of neuronal reuptake of serotonin
• Selective inhibitor of neuronal serotonin reuptake
• Weak effects on norepinephrine and dopamine neuronal reuptake
• Little affinity for various receptors

Dosage and Administration

• Usual Initial Dosage: 20 mg/day for Major Depressive Disorder
• Maintenance Therapy: Efficacy maintained with average dose of 30 mg for 1 year
• Usual Initial Dosage: 40 mg/day for Obsessive Compulsive Disorder
• Maintenance Therapy: Dosage adjustments for lowest effective dosage
• Usual Initial Dosage: 40 mg/day for Panic Disorder
• Maximum dosage: 60 mg/day
• Usual Initial Dosage: 20 mg/day for Social Anxiety Disorder
• Usual Initial Dosage: 20 mg/day for Generalized Anxiety Disorder
• Usual Initial Dosage: 20 mg/day for Posttraumatic Stress Disorder

Interactions

• Absorption and pharmacokinetics not affected by food or antacids
• Potential interaction with Tryptophan causing serotonin syndrome
• Metabolism affected by drugs which induce or inhibit hepatic drug metabolizing enzymes
• Concomitant use with alcohol not advised
• Potential interaction with MAO inhibitors
• Potential interaction with lithium
• Co-administration with phenytoin associated with decreased plasma concentrations
• Preliminary data suggests pharmacodynamic interaction with warfarin

Contradictions

• Contraindicated in patients taking MAOIs or thioridazine
• Contraindicated in patients with hypersensitivity to Paroxetine

Side Effects

• Asthenia
• Sweating
• Nausea
• Decreased appetite
• Somnolence
• Dizziness
• Insomnia
• Tremor
• Nervousness
• Ejaculatory disturbance
• Dry mouth
• Constipation
• Decreased libido
• Female genital disorders
• Impotence
• Abnormal ejaculation
• Yawn
• Infection

Pregnancy and Lactation

• Use during pregnancy if potential benefit justifies the potential risk
• The effect on labor and delivery in humans is unknown
• Paroxetine is secreted in human milk

Precautions and Warnings

• Caution advised when treating patients with cardiac conditions
• Use with caution in patients with epilepsy
• Discontinue in patients who develop seizures
• Little clinical experience of concurrent administration with ECT
• Not associated with impairment of cognitive or psychomotor function
• Taper phase regimen advised for discontinuation of treatment
• Recommended initial dose of 10 mg/day for elderly or debilitated patients
• Dosage should not exceed 40 mg/day

Use in Special Populations

• Recommended initial dose of 10 mg/day for elderly, debilitated, and severe renal or hepatic impairment patients

Therapeutic Class

• SSRIs & related antidepressant drugs

Storage Conditions

• Store at a cool and dry place
• Protect from light and moisture

Related Brands

• Melev 20 mg (Tablet) - beximco-pharmaceuticals-ltd