Andep 50 mg (Tablet)
Medicine Details
| Category | Details |
|---|---|
| Generic | Sertraline hydrochloride |
| Company | Healthcare pharmaceuticals ltd |
| Also available as |
Indications
- Major depressive disorder (MDD)
- Obsessive-compulsive disorder (OCD)
- Panic disorder (PD)
- Post-traumatic stress disorder (PTSD)
- Social anxiety disorder (SAD)
- Premenstrual dysphoric disorder (PMDD)
Pharmacology
Potent and selective inhibitory action on CNS neuronal reuptake of 5-HT resulting in increased 5-HT concentrations at the synaptic clefts, leading to facilitation of its sustained activity at the postsynaptic receptor sites. Reduction of Serotonin turnover in brain by Sertraline is also another contributing fact implicated in its action. Prolonged elimination half-life offers a benefit of once daily administration.
Dosage & Administration
- Adults:
- Major depressive disorder:
- Starting Dose: 50 mg
- Therapeutic Range: 50-200 mg
- Obsessive-compulsive disorder:
- Starting Dose: 50 mg
- Therapeutic Range: 50-200 mg
- Panic disorder,Post-traumatic stress disorder,Social anxiety disorder:
- Starting Dose: 25 mg
- Therapeutic Range: 50-200 mg
- Major depressive disorder:
- Pediatric Patients (ages 6-12 years old):
- Obsessive-compulsive disorder:
- Starting Dose: 25 mg
- Therapeutic Range: 50-200 mg
- Obsessive-compulsive disorder:
- Premenstrual dysphoric disorder (PMDD):
- Starting dosage for PMDD is 50 mg/day.
- Recommended interval between dose changes is one week.
- Continuous: Patients not responding to a 50 mg dosage may benefit from dosage increases at 50 mg increments per menstrual cycle up to 150 mg per day.
- Intermittent: Patients not responding to a 50 mg dosage may benefit from increasing the dosage up to a maximum of 100 mg per day during the next menstrual cycle (and subsequent cycles).
Interaction
Potential effects of co-administration of drugs that are highly bound to plasma proteins. Andep may interact with other drugs such as Cimetidine, CNS active drugs like Diazepam, Hypoglycemic drugs, Atenolol etc.
Contraindications
Contraindicated in patients with a known hypersensitivity to Sertraline or any of the excipients of drug. In patients with moderate to severe hepatic impairment is not recommended.
Side Effects
- Upset stomach
- Diarrhoea
- Constipation
- Vomiting
- Dry mouth
- Loss of appetite
- Weight changes
- Drowsiness
- Dizziness
- Headache
- Pain
- Burning or tingling in the hands or feet
- Excitement
- Sore throat
Pregnancy & Lactation
Although animal studies did not provide any evidence of teratogenicity, the safety of Sertraline during human pregnancy has not been established. Sertraline is known to be excreted in breast milk. Its effects on the nursing infant have not yet been established. If treatment with Sertraline is considered necessary, discontinuation of breast-feeding should be considered.
Precautions & Warnings
- Conditions to be cautious about:
- Liver problems
- Kidney diseases
- Seizures
- Heart problems
- Allergies
- Possible effects: Dizziness or drowsiness
Therapeutic Class
SSRIs & related anti-depressant drugs
Storage Conditions
Do not store above 30°C. Keep out of the reach of children.