Repose 25 mg (Tablet)

Unit Price: ৳ 3.50 (5 x 10: ৳ 175.00)

Strip Price: ৳ 35.00

Medicine Details

Category	Details
Generic	Sertraline hydrochloride
Company	Incepta pharmaceuticals ltd
Also available as	Repose 50 mg tablet Repose 100 mg tablet

Title

Repose

Description

Repose is indicated for the treatment of major depressive disorder (MDD), obsessive-compulsive disorder (OCD), panic disorder (PD), post-traumatic stress disorder (PTSD), social anxiety disorder (SAD), and premenstrual dysphoric disorder (PMDD). It has a pharmacological action of inhibiting CNS neuronal reuptake of 5-HT, leading to increased 5-HT concentrations at the synaptic clefts. The recommended dosage for adults varies depending on the indication, and caution is advised for pediatric patients, pregnant or lactating women, and elderly individuals. Repose may interact with other drugs and has potential side effects like upset stomach, dizziness, and drowsiness. It belongs to the therapeutic class of SSRIs & related anti-depressant drugs, and should be stored below 30°C, out of the reach of children.

Indications

Major depressive disorder (MDD)
Obsessive-compulsive disorder (OCD)
Panic disorder (PD)
Post-traumatic stress disorder (PTSD)
Social anxiety disorder (SAD)
Premenstrual dysphoric disorder (PMDD)

Mode of Action

Potent and selective inhibitory action on CNS neuronal reuptake of 5-HT resulting in increased 5-HT concentrations at the synaptic clefts, leading to facilitation of its sustained activity at the postsynaptic receptor sites

Dosage & Administration

Adults:
- Major depressive disorder:
  - Starting Dose: 50 mg
  - Therapeutic Range: 50-200 mg
- Obsessive-compulsive disorder:
  - Starting Dose: 50 mg
  - Therapeutic Range: 50-200 mg
- Panic disorder, Post-traumatic stress disorder, Social anxiety disorder:
  - Starting Dose: 25 mg
  - Therapeutic Range: 50-200 mg
Pediatric Patients (ages 6-12 years old):
- Obsessive-compulsive disorder:
  - Starting Dose: 25 mg
  - Therapeutic Range: 50-200 mg
Premenstrual dysphoric disorder (PMDD):
- Starting dosage: 50 mg/day
- Continuous: Patients not responding to a 50 mg dosage may benefit from dosage increases at 50 mg increments per menstrual cycle up to 150 mg per day
- Intermittent: Patients not responding to a 50 mg dosage may benefit from increasing the dosage up to a maximum of 100 mg per day during the next menstrual cycle (and subsequent cycles)
Interval between dose changes: one week

Interaction

Potential effects of co-administration of drugs that are highly bound to plasma proteins, as Repose is tightly bound to plasma protein. Repose may interact with drugs such as Cimetidine, Diazepam, Hypoglycemic drugs, and Atenolol

Contraindications

Known hypersensitivity to Sertraline or any of the excipients of drug
Moderate to severe hepatic impairment

Side Effects

Upset stomach
Diarrhoea
Constipation
Vomiting
Dry mouth
Loss of appetite
Weight changes
Drowsiness
Dizziness
Headache
Pain
Burning or tingling in the hands or feet
Excitement
Sore throat

Pregnancy & Lactation

Pregnancy: Safety not established
Lactation: Discontinuation of breastfeeding should be considered if treatment with Repose is necessary, as it is excreted in breast milk

Precautions & Warnings

Conditions requiring caution:
- Liver problems
- Kidney diseases
- Seizures
- Heart problems
- Allergies
Effects on alertness: Dizziness or drowsiness, caution required for activities requiring alertness
Elderly use: Caution advised
Monoamine oxidase inhibitor: Do not take Repose if taken within the last five weeks
Monitoring: Close monitoring for suicidal thinking and behavioral changes