Serolux 50 mg (Tablet)

Unit Price: ৳ 7.10 (5 x 10: ৳ 355.00)

Strip Price: ৳ 71.00

Medicine Details

Category	Details
Generic	Sertraline hydrochloride
Company	Sandoz a novartis division
Also available as	Serolux 25 mg tablet Serolux 100 mg tablet

Indications

Major depressive disorder (MDD)
Obsessive-compulsive disorder (OCD)
Panic disorder (PD)
Post-traumatic stress disorder (PTSD)
Social anxiety disorder (SAD)
Premenstrual dysphoric disorder (PMDD)

Pharmacology

Potent and selective inhibitory action on CNS neuronal reuptake of 5-HT resulting in increased 5-HT concentrations at the synaptic clefts, leading to facilitation of its sustained activity at the postsynaptic receptor sites. Reduction of Serotonin turnover in brain by Sertraline is also another contributing factor implicated in its action. Prolonged elimination half-life offers a benefit of once daily administration.

Dosage & Administration

Adults:
- Major depressive disorder:
  - Starting Dose: 50 mg
  - Therapeutic Range: 50-200 mg
- Obsessive-compulsive disorder:
  - Starting Dose: 50 mg
  - Therapeutic Range: 50-200 mg
- Panic disorder, Post-traumatic stress disorder, Social anxiety disorder:
  - Starting Dose: 25 mg
  - Therapeutic Range: 50-200 mg
Pediatric Patients (ages 6-12 years old):
- Obsessive-compulsive disorder:
  - Starting Dose: 25 mg
  - Therapeutic Range: 50-200 mg
Premenstrual dysphoric disorder (PMDD):
- Starting dosage for PMDD is 50 mg/day
- May be administered either continuously (every day throughout the menstrual cycle) or intermittently (starting the daily dosage 14 days prior to the anticipated onset of menstruation and continuing through the onset of menses)
- Patients not responding to a 50 mg dosage may benefit from dosage increases at 50 mg increments per menstrual cycle up to 150 mg per day
- Patients not responding to a 50 mg dosage may benefit from increasing the dosage up to a maximum of 100 mg per day during the next menstrual cycle (and subsequent cycles)
Recommended interval between dose changes: one week

Interactions

May interact with drugs that are highly bound to plasma proteins such as warfarin, digitoxin, cimetidine, CNS active drugs like diazepam, hypoglycemic drugs, and atenolol

Contraindications

Known hypersensitivity to Sertraline or any of the excipients of drug
Moderate to severe hepatic impairment

Side Effects

Upset stomach
Diarrhoea
Constipation
Vomiting
Dry mouth
Loss of appetite
Weight changes
Drowsiness
Dizziness
Headache
Pain
Burning or tingling in the hands or feet
Excitement
Sore throat

Pregnancy & Lactation

Evidence in animal studies: No evidence of teratogenicity
Safety during human pregnancy: Not established
Excretion in breast milk: Present
Effects on the nursing infant: Not yet established
Consideration for treatment: Discontinuation of breast-feeding should be considered

Precautions & Warnings

Conditions requiring caution:
- Liver problems
- Kidney diseases
- Seizures
- Heart problems
- Allergies
Potential effects: Dizziness or drowsiness
Caution in activities: Requiring alertness such as driving or using machinery
Elderly patients: More sensitive to the effects of the drug
Avoidance with monoamine oxidase inhibitor: In the last five weeks
Risk of suicidal thinking: Close monitoring of the patient after 2 to 3 weeks of use is required