Sertal 50 mg (Tablet)
Medicine Details
| Category | Details |
|---|---|
| Generic | Sertraline hydrochloride |
| Company | Drug international ltd |
| Also available as |
Indications
- Major depressive disorder (MDD)
- Obsessive-compulsive disorder (OCD)
- Panic disorder (PD)
- Post-traumatic stress disorder (PTSD)
- Social anxiety disorder (SAD)
- Premenstrual dysphoric disorder (PMDD)
Pharmacology
Potent and selective inhibitory action on CNS neuronal reuptake of 5-HT resulting in increased 5-HT concentrations at the synaptic clefts, leading to facilitation of its sustained activity at the postsynaptic receptor sites. Reduction of Serotonin turnover in brain is another contributing factor implicated in its action. Prolonged elimination half-life offers a benefit of once daily administration.
Dosage & Administration
- Adults:
- Starting Dose: 50 mg
- Therapeutic Range: 50-200 mg
- Pediatric Patients (ages 6-12 years old):
- Starting Dose: 25 mg
- Therapeutic Range: 50-200 mg
- Premenstrual dysphoric disorder (PMDD):
- Starting dosage for PMDD is 50 mg/day. Sertraline may be administered either continuously (every day throughout the menstrual cycle) or intermittently (starting the daily dosage 14 days prior to the anticipated onset of menstruation and continuing through the onset of menses). Intermittent dosing would be repeated with each new cycle.
- Continuous: Patients not responding to a 50 mg dosage may benefit from dosage increases at 50 mg increments per menstrual cycle up to 150 mg per day.
- Intermittent: Patients not responding to a 50 mg dosage may benefit from increasing the dosage up to a maximum of 100 mg per day during the next menstrual cycle (and subsequent cycles)
Interaction
Potential effects of co-administration of drugs that are highly bound to plasma proteins. Sertal may interact with other drugs such as Cimetidine, CNS active drugs like Diazepam, Hypoglycemic drugs, Atenolol etc.
Contraindications
- Known hypersensitivity to Sertraline or any of the excipients of the drug
- Moderate to severe hepatic impairment
Side Effects
- Upset stomach
- Diarrhea
- Constipation
- Vomiting
- Dry mouth
- Loss of appetite
- Weight changes
- Drowsiness
- Dizziness
- Headache
- Pain
- Burning or tingling in the hands or feet
- Excitement
- Sore throat
Pregnancy & Lactation
Safety during human pregnancy and effects on nursing infant have not been established; discontinuation of breast-feeding should be considered if treatment is necessary
Precautions & Warnings
- Liver problems
- Kidney diseases
- Seizures
- Heart problems
- Allergies
- Dizziness or drowsiness
- Caution in activities requiring alertness
- Elderly sensitivity
- Do not take with monoamine oxidase inhibitor
- Risks of suicidal thinking and behavioral changes
Therapeutic Class
SSRIs & related anti-depressant drugs
Storage Conditions
Do not store above 30°C. Keep out of the reach of children