Setra 25 mg (Tablet)
Medicine Details
| Category | Details |
|---|---|
| Generic | Sertraline hydrochloride |
| Company | General pharmaceuticals ltd |
| Also available as |
Indications
- Major depressive disorder (MDD)
- Obsessive-compulsive disorder (OCD)
- Panic disorder (PD)
- Post-traumatic stress disorder (PTSD)
- Social anxiety disorder (SAD)
- Premenstrual dysphoric disorder (PMDD)
Pharmacology
Potent and selective inhibitory action on CNS neuronal reuptake of 5-HT resulting in increased 5-HT concentrations at the synaptic clefts, leading to facilitation of its sustained activity at the postsynaptic receptor sites. Reduction of Serotonin turnover in brain is another contributing factor implicated in its action. Prolonged elimination half-life offers a benefit of once daily administration.
Dosage & Administration - Adults
- Major depressive disorder:
- Starting Dose: 50 mg
- Therapeutic Range: 50-200 mg
- Obsessive-compulsive disorder:
- Starting Dose: 50 mg
- Therapeutic Range: 50-200 mg
- Panic disorder, Post-traumatic stress disorder, Social anxiety disorder:
- Starting Dose: 25 mg
- Therapeutic Range: 50-200 mg
Dosage & Administration - Pediatric Patients (ages 6-12 years old)
- Obsessive-compulsive disorder:
- Starting Dose: 25 mg
- Therapeutic Range: 50-200 mg
Dosage & Administration - Premenstrual dysphoric disorder (PMDD)
- Starting dosage: 50 mg/day
- Continuous: Patients not responding to a 50 mg dosage may benefit from dosage increases at 50 mg increments per menstrual cycle up to 150 mg per day.
- Intermittent: Patients not responding to a 50 mg dosage may benefit from increasing the dosage up to a maximum of 100 mg per day during the next menstrual cycle (and subsequent cycles)
Interaction
Potential effects of co-administration of drugs that are highly bound to plasma proteins. Setra may interact with drugs such as Cimetidine, CNS active drugs like Diazepam, Hypoglycemic drugs, Atenolol etc.
Contraindications
- Known hypersensitivity to Sertraline or any of the excipients of the drug
- Moderate to severe hepatic impairment
Side Effects
- Upset stomach
- Diarrhoea
- Constipation
- Vomiting
- Dry mouth
- Loss of appetite
- Weight changes
- Drowsiness
- Dizziness
- Headache
- Pain
- Burning or tingling in the hands or feet
- Excitement
- Sore throat
Pregnancy & Lactation
Safety during human pregnancy has not been established. Excreted in breast milk. Effects on the nursing infant have not yet been established. Discontinuation of breast-feeding should be considered if treatment with Sertraline is necessary.
Precautions & Warnings
- Special Precautions:
- Liver problems
- Kidney diseases
- Seizures
- Heart problems
- Allergies
- Caution:
- Dizziness or drowsiness
- Activities requiring alertness such as driving or using machinery
- Elderly use, as they may be more sensitive to the effects of the drug
- Avoid if MAO inhibitor has been taken in the last five weeks
- Risk of suicidal thinking and change of behavior may occur
Therapeutic Class
SSRIs & related anti-depressant drugs
Storage Conditions
Do not store above 30°C. Keep out of the reach of children.