Zosert 25 mg (Tablet)

Unit Price: ৳ 3.01 (5 x 10: ৳ 150.50)

Strip Price: ৳ 30.10

Medicine Details

Category	Details
Generic	Sertraline hydrochloride
Company	Sun pharmaceutical bangladesh ltd
Also available as	Zosert 50 mg tablet Zosert 100 mg tablet

Indications

Major depressive disorder (MDD)
Obsessive-compulsive disorder (OCD)
Panic disorder (PD)
Post-traumatic stress disorder (PTSD)
Social anxiety disorder (SAD)
Premenstrual dysphoric disorder (PMDD)

Pharmacology

Sertraline has potent and selective inhibitory action on CNS neuronal reuptake of 5-HT resulting in increased 5-HT concentrations at the synaptic clefts, leading to facilitation of its sustained activity at the postsynaptic receptor sites. It ultimately results in an improvement of depression. Reduction of Serotonin turnover in the brain by Sertraline is also another contributing factor implicated in its action. Its prolonged elimination half-life offers a benefit of once daily administration.

Dosage & Administration

Adults:
- Major depressive disorder:
  - Starting Dose: 50 mg
  - Therapeutic Range: 50-200 mg
- Obsessive-compulsive disorder:
  - Starting Dose: 50 mg
  - Therapeutic Range: 50-200 mg
- Panic disorder, Post-traumatic stress disorder, Social anxiety disorder:
  - Starting Dose: 25 mg
  - Therapeutic Range: 50-200 mg
Pediatric Patients (ages 6-12 years old):
- Obsessive-compulsive disorder:
  - Starting Dose: 25 mg
  - Therapeutic Range: 50-200 mg
Premenstrual dysphoric disorder (PMDD):
- Continuous: Patients not responding to a 50 mg dosage may benefit from dosage increases at 50 mg increments per menstrual cycle up to 150 mg per day.
- Intermittent: Patients not responding to a 50 mg dosage may benefit from increasing the dosage up to a maximum of 100 mg per day during the next menstrual cycle (and subsequent cycles).

Interaction

Potential effects of co-administration of drugs that are highly bound to plasma proteins- As Zosert is tightly bound to plasma protein, the administration of Zosert to a patient taking another drug which is tightly bound to protein, (e.g. warfarin, digitoxin) may cause a shift in plasma concentrations potentially resulting in an adverse effect. Conversely adverse effects may result from displacement of protein-bound Zosert by other tightly bound drugs. Zosert may interact with other drugs such as Cimetidine, CNS active drugs like Diazepam, Hypoglycemic drugs, Atenolol etc.

Contraindications

Sertraline is contraindicated in patients with a known hypersensitivity to Sertraline or any of the excipients of the drug. In patients with moderate to severe hepatic impairment, it is not recommended.

Side Effects

Upset stomach
Diarrhoea
Constipation
Vomiting
Dry mouth
Loss of appetite
Weight changes
Drowsiness
Dizziness
Headache
Pain
Burning or tingling in the hands or feet
Excitement
Sore throat

Pregnancy & Lactation

Although animal studies did not provide any evidence of teratogenicity, the safety of Sertraline during human pregnancy has not been established. Sertraline is known to be excreted in breast milk. Its effects on the nursing infant have not yet been established. If treatment with Sertraline is considered necessary, discontinuation of breastfeeding should be considered.

Precautions & Warnings

Precaution should be taken in the case of liver problems, kidney diseases, seizures, heart problems, and any allergies. Zosert may cause dizziness or drowsiness. Caution should be taken in activities requiring alertness such as driving or using machinery. Caution is advised while using Zosert in the elderly because they may be more sensitive to the effects of the drug. Do not take Zosert if you have taken monoamine oxidase inhibitors in the last five weeks. Risk of suicidal thinking and change of behavior may occur (close monitoring of the patient after 2 to 3 weeks of use is required).