Zosert 100 mg (Tablet)

Unit Price: ৳ 10.03 (3 x 10: ৳ 300.90)

Strip Price: ৳ 100.30

Medicine Details

Category	Details
Generic	Sertraline hydrochloride
Company	Sun pharmaceutical bangladesh ltd
Also available as	Zosert 50 mg tablet Zosert 25 mg tablet

Indications

Major depressive disorder (MDD)
Obsessive-compulsive disorder (OCD)
Panic disorder (PD)
Post-traumatic stress disorder (PTSD)
Social anxiety disorder (SAD)
Premenstrual dysphoric disorder (PMDD)

Pharmacology

Sertraline has potent and selective inhibitory action on CNS neuronal reuptake of 5-HT resulting in increased 5-HT concentrations at the synaptic clefts, leading to facilitation of its sustained activity at the postsynaptic receptor sites. Its prolonged elimination half-life offers a benefit of once daily administration.

Dosage & Administration

Adults:
- Major depressive disorder:
  - Starting Dose: 50 mg
  - Therapeutic Range: 50-200 mg
- Obsessive-compulsive disorder:
  - Starting Dose: 50 mg
  - Therapeutic Range: 50-200 mg
- Panic disorder, Post-traumatic stress disorder, Social anxiety disorder:
  - Starting Dose: 25 mg
  - Therapeutic Range: 50-200 mg
Pediatric Patients (ages 6-12 years old):
- Obsessive-compulsive disorder:
  - Starting Dose: 25 mg
  - Therapeutic Range: 50-200 mg
Premenstrual dysphoric disorder (PMDD):
- Starting dosage for PMDD is 50 mg/day. Sertraline may be administered either continuously (every day throughout the menstrual cycle) or intermittently.

Interaction

Potential effects of co-administration of drugs that are highly bound to plasma proteins. Zosert may interact with other drugs such as Cimetidine, CNS active drugs like Diazepam, Hypoglycemic drugs, Atenolol etc.

Contraindications

Sertraline is contraindicated in patients with a known hypersensitivity to Sertraline or any of the excipients of drug. In patients with moderate to severe hepatic impairment, it is not recommended.

Side Effects

Upset stomach
Diarrhoea
Constipation
Vomiting
Dry mouth
Loss of appetite
Weight changes
Drowsiness
Dizziness
Headache
Pain
Burning or tingling in the hands or feet
Excitement
Sore throat

Pregnancy & Lactation

Although animal studies did not provide any evidence of teratogenicity, the safety of Sertraline during human pregnancy has not been established. Sertraline is known to be excreted in breast milk. If treatment with Sertraline is considered necessary, discontinuation of breast-feeding should be considered.

Precautions & Warnings

Precaution should be taken in case of liver problems, kidney diseases, seizures, heart problems and any allergies. Zosert may cause dizziness or drowsiness. Do not take Zosert if you have taken monoamine oxidase inhibitor in the last five weeks. Risk of suicidal thinking and change of behavior may occur.