Mitrazin 30 mg (Tablet)

Unit Price: ৳ 17.00 (3 x 10: ৳ 510.00)
Strip Price: ৳ 170.00

Medicine Details

Category Details
Generic Mirtazapine
Company General pharmaceuticals ltd
Also available as
Mitrazin 15 mg tablet Mitrazin 75 mg tablet

Indications

  • Treatment of major depressive disorder (MDD)

Pharmacology

  • Unknown mechanism of action
  • Enhances central noradrenergic and serotonergic activity
  • Acts as an antagonist at central presynaptic α2-adrenergic inhibitory autoreceptors and heteroreceptors
  • Potent antagonist of 5-HT2 and 5-HT3 receptors
  • Moderate peripheral α1-adrenergic antagonist
  • Moderate antagonist at muscarinic receptors
  • Potent antagonist of histamine (H1) receptors
  • Rapid and well-absorbed after oral administration
  • Half-life of elimination is 20-40 hours
  • Extensively metabolized and eliminated via urine and feces

Dosage & Administration

  • Recommended starting dose is 15 mg/day
  • Effective dose range is 15 to 45 mg/day
  • Once-a-day dosing
  • Recommended administration in the evening or prior to sleep
  • Dose changes should be made at intervals of less than 1 to 2 weeks
  • Not recommended for use in children

Interaction

  • Clinically significant interactions with Monoamine Oxidase Inhibitors (MAOI) and other serotonergic drugs
  • May interrupt the metabolism or activity of Carbamazepine, Phenytoin, or Cimetidine
  • Patients should avoid Alcohol and Diazepam while taking the medication

Contraindications

  • Contraindicated in patients with known hypersensitivity to Mirtazapine or its excipients
  • Contraindicated with concomitant use of a monoamine oxidase (MAO) inhibitor
  • Should not be used within 14 days of initiating or discontinuing therapy with a MAOI

Side Effects

  • Common side effects include dizziness, drowsiness, dry mouth, increased appetite, and weight gain

Pregnancy & Lactation

  • Pregnancy Category-C
  • Patients should notify their physician if they become pregnant or intend to become pregnant during therapy
  • Patients should notify their physician if they are breastfeeding

Precautions & Warnings

  • Patients, families, and caregivers should be alert to the emergence of various behavioral changes and suicidal ideation
  • Patients should be warned about the risk of developing agranulocytosis
  • May impair judgment, thinking, and motor skills due to sedative effect
  • Clinically significant ALT (SGPT) elevations may occur

Therapeutic Class

  • Atypical anti-depressant drugs

Storage Conditions

  • Store below 30°C
  • Keep away from light and moisture
  • Keep out of the reach of children

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