Rapine 30 mg (Tablet)

Unit Price: ৳ 15.00 (3 x 10: ৳ 450.00)
Strip Price: ৳ 150.00

Medicine Details

Category Details
Generic Mirtazapine
Company Aci limited
Also available as
Rapine 15 mg tablet Rapine 75 mg tablet

Title and Categories

  • Rapine Tablets
  • Atypical anti-depressant drugs

Function

  • Treatment of major depressive disorder (MDD)

Pharmacology

  • Unknown mechanism of action for treating MDD
  • Enhances central noradrenergic and serotonergic activity
  • Antagonist at central presynaptic α2-adrenergic inhibitory autoreceptors and heteroreceptors
  • Potent antagonist of 5- HT<sub>2</sub> and 5-HT<sub>3</sub> receptors
  • Moderate peripheral &alpha;1-adrenergic antagonist
  • Moderate antagonist at muscarinic receptors
  • Sedative effects due to histamine (H<sub>1</sub>) receptors antagonism
  • Extensively metabolized and eliminated via urine and faeces

Dosage & Administration

  • Recommended starting dose of 15 mg/day
  • Effective dose range of 15 to 45 mg/day
  • Elimination half-life of 20 to 40 hours
  • Avoid use in children
  • Instructions for missed dose

Interaction

  • Clinically significant drug-drug interactions with MAOI & other serotonergic drugs
  • May interrupt the metabolism or activity of Carbamazepine, Phenytoin or Cimetidine
  • Patient should avoid Alcohol & Diazepam while taking Rapine

Contraindications

  • Contraindicated in patients with known hypersensitivity to Mirtazapine or excipients
  • Concomitant use with MAO inhibitors is contraindicated

Side Effects

  • Dizziness
  • Drowsiness
  • Dry mouth
  • Increased appetite
  • Weight gain

Pregnancy & Lactation

  • Pregnancy Category-C
  • Patients advised to notify physician if pregnant or intend to become pregnant during therapy
  • Patients advised to notify physician if breastfeeding

Precautions & Warnings

  • Patient, families, and caregivers should be alert to the emergence of certain neuropsychiatric events
  • Clinically significant ALT (SGPT) elevations may occur
  • Rapine may impair judgment, thinking, and motor skills

Storage Conditions

  • Keep away from light and moisture
  • Store below 30&ordm; C
  • Keep all medicine out of the reach of children

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