Venlax 37.5 mg (Tablet)

Indications

• Treatment of major depressive disorder
• Effective in controlling symptoms of major depression
• Maintenance of antidepressant response
• Long-term usefulness evaluation
• Treatment duration
• Usability for recurrent depression
• Tolerability
• Dosage adjustment for elderly patients

Pharmacology

• Mechanism of action unknown
• Potentiation of neurotransmitter activity in CNS
• Inhibition of serotonin and norepinephrine reuptake
• Weak inhibitory effects on dopamine reuptake
• Inactive at histaminergic, muscarinic, and alpha(1)-adrenergic receptors

Dosage & Administration

• Recommended starting dose of 75 mg/day
• Administration in two or three divided doses
• Dosing increment intervals
• No dose adjustment for elderly patients
• Maintenance treatment duration
• Discontinuation symptoms monitoring
• Gradual dose reduction recommendation

Interaction

• Increased risk of serotonin syndrome
• Serum level increase with CYP3A4 inhibitors
• Serum level increase of haloperidol
• Serum level decrease of indinavir
• Increased bleeding risk

Contraindications

• Concomitant use with MAOIs
• Use within 14 days of discontinuing MAOI
• Contraindicated with linezolid or IV methylene blue

Side Effects

• Behavioral changes
• Suicidal ideation
• Nervous system effects
• Digestive system effects
• Cardiovascular effects
• Genitourinary effects
• Visual and sensory effects
• Dermatological effects
• Respiratory effects
• Weight changes
• Musculoskeletal effects

Pregnancy & Lactation

• Neonatal complications
• Consideration of risks and benefits in third trimester

Precautions & Warnings

• History of specific conditions
• Renal and hepatic impairment
• Caution in gradual dose reduction
• Impairment of cognitive abilities

Use in Special Populations

• Dosage adjusted for hepatic impairment
• Individualized dosing for cirrhosis patients
• Dosage adjustment for renal impairment
• Individualized dosing for renal impairment

Overdose Effects

• Symptoms of overdose
• Symptomatic and supportive treatment
• Airway, oxygenation, and ventilation management
• Gastric lavage and activated charcoal administration

Therapeutic Class

• Serotonin-norepinephrine reuptake inhibitor (SNRI)

Storage Conditions

• Storage temperature: 20-25°C

Related Brands

• Venlax 75 mg (Tablet) - general-pharmaceuticals-ltd