Amival 0.5 mg+10 mg (Tablet)
Medicine Details
| Category | Details |
|---|---|
| Generic | Fluphenazine nortriptyline |
| Company | Amico laboratories ltd |
Indications
- Mild to moderate mixed anxiety/depression
- Emotional disturbance
- Sleep disorder
- Gastric problems
Description
Fluphenazine is a tranquilizer of the phenothiazine type. Nortriptyline is a tricyclic antidepressant having less sedative action. Amival has been found as effective preparation for the patients suffering from 'anxiety' or 'depression' or both and helps to restore functional ability without developing any drug dependence.
Pharmacology
- Nortriptyline hydrochloride: Nortriptyline inhibits the uptake of norepinephrine and serotonin at nerve terminals. In contrast to its parent compound amitriptyline which is equally potent in inhibiting the uptake of norepinephrine and serotonin, Nortriptyline has a greater effect on norepinephrine reuptake than on serotonin reuptake.
- Fluphenazine: Fluphenazine primarily acts as a neuroleptic drug whose main therapeutic effect is believed to reside in potent dopamine (specially D2) receptor antagonism.
Dosage & Administration
Adults: One tablet 2 to 3 times daily.
Interaction
Interactions with barbiturates, alcohol, and narcotic drugs may occur, so central depressants should be administered with caution.
Contraindications
- History of gradual epilepsy or organic brain damage
- Blood dyscrasia
- Severe cardiac insufficiency
- Renal or liver damage
- Patients taking monoamine oxidase inhibitor (MAOI)
- Younger children
- Hypersensitivity to any component of the preparation
Side Effects
Tardive dyskinesias, Blood dyscrasia, Malignant Neuroleptic syndrome, sudden death, Agranulocytosis
Pregnancy & Lactation
The safety in human pregnancy has not been yet established. The use of this drug in lactation is not recommended, as it is excreted in breast milk.
Precautions & Warnings
Precautions should be taken in patients with glaucoma, prostate enlargement, cardiac failure, myocardial infarction, and in concurrent administration with CNS depressants. The drug may impair alertness and abilities to drive a car or operate machinery.
Therapeutic Class
Combined anxiolytics & anti-depressant drugs
Storage Conditions
Keep below 30°C temperature, away from light & moisture. Keep out of the reach of children.