Apresin 0.5 mg+10 mg (Tablet)
Medicine Details
| Category | Details |
|---|---|
| Generic | Fluphenazine nortriptyline |
| Company | Beximco pharmaceuticals ltd |
Indications
- Mild to moderate mixed anxiety/depression
- Emotional disturbance
- Sleep disorder
- Gastric problems
Description
Tranquilizer of the phenothiazine type combined with a tricyclic antidepressant effective for patients suffering from anxiety or depression, restoring functional ability without developing drug dependence
Pharmacology
- Nortriptyline hydrochloride: Inhibits the uptake of norepinephrine and serotonin at nerve terminals
- Fluphenazine: Acts as a neuroleptic drug with potent dopamine (especially D2) receptor antagonism
Dosage & Administration
Adults: One tablet 2 to 3 times daily
Interaction
Interactions with barbiturates, alcohol, and narcotic drugs may occur
Contraindications
- History of gradual epilepsy or organic brain damage
- Blood dyscrasia
- Severe cardiac insufficiency
- Renal or liver damage
- Patients taking monoamine oxidase inhibitor (MAOI)
- Younger children
- Hypersensitivity to any component of the preparation
Side Effects
Tardive dyskinesias, blood dyscrasia, malignant neuroleptic syndrome, sudden death, agranulocytosis
Pregnancy & Lactation
Safety in human pregnancy not established, not recommended during lactation as it is excreted in breast milk
Precautions & Warnings
Precautions in patients with glaucoma, prostate enlargement, cardiac failure, myocardial infarction, and in concurrent administration with CNS depressants. May impair alertness and abilities to drive or operate machinery
Therapeutic Class
Combined anxiolytics & anti-depressant drugs
Storage Conditions
Keep below 30°C, away from light & moisture, out of reach of children