Avonex 25 mg+50 mg (Tablet)

Unit Price: ৳ 2.51 (30's pack: ৳ 75.22)

Medicine Details

Category Details
Generic Meclizine pyridoxine
Company Novo healthcare and pharma ltd

Indications

  • Prevention and treatment of nausea
  • Prevention and treatment of vomiting
  • Prevention and treatment of dizziness
  • Prevention and treatment of motion sickness
  • Prevention and treatment of radiation sickness
  • Prevention and treatment of vertigo associated with diseases of the vestibular system

Pharmacology

  • Meclizine is a piperazine-derivative antihistamine
  • Has antiemetic properties
  • Has anticholinergic properties
  • Has antihistaminic properties
  • Reduces the sensitivity of the labyrinthine apparatus
  • The action may be mediated through nerve pathways to the vomiting center (VC) from the chemoreceptor trigger zone (CTZ), peripheral nerve pathways, the VC, or other CNS centers
  • Pyridoxine is vitamin B-6
  • Enhances the anti-emetic effects
  • Acts as a dietary supplement

Dosage & Administration

  • Dosage for adults and children aged 12 and over
  • Nausea and vomiting dosage: 25-50 mg daily or as directed by a physician
  • Motion sickness dosage: Take an initial dose of 25-50 mg, 1 hour prior to travel; may repeat every 24 hours for the duration of the journey
  • Radiation sickness dosage: 50 mg administered 2-12 hours prior to radiation treatment
  • Vertigo dosage: 25-100 mg daily in divided doses
  • Prevention of nausea and vomiting associated with emergency contraceptive pill (ECP) dosage: 25-50 mg, 1 hour before first ECP dose; repeat if needed in 24 hours
  • Safety and efficacy for use in children less than 12 years of age not established

Interaction

  • CNS depressant effects can be potentiated by Ethanol or other CNS depressant agents
  • Potentiation by Benzodiazepines
  • Potentiation by Barbiturates
  • Potentiation by Tricyclic antidepressants
  • Potentiation by Opiate agonists
  • Potentiation by Skeletal muscle relaxants
  • Potentiation by Antihistamines
  • Anticholinergics can potentiate the anticholinergic effects
  • Meclizine can increase the absorption of digoxin by decreasing gastrointestinal motility

Contraindications

  • Contraindicated in patients who are hypersensitive to Meclizine Hydrochloride
  • Contraindicated in patients who are hypersensitive to Pyridoxine Hydrochloride

Side Effects

  • Drowsiness
  • Dry mouth
  • Blurred vision (rare)

Pregnancy & Lactation

  • Pregnancy Category B
  • Large-scale human studies have not demonstrated adverse fetal effects
  • Meclizine presents the lowest risk of teratogenicity
  • Drug of first choice in treating nausea and vomiting during pregnancy
  • Safety for use in the nursing mother not established

Precautions & Warnings

  • May impair the ability to perform hazardous activities requiring mental alertness or physical coordination
  • Patients should avoid alcoholic beverages while taking Meclizine Hydrochloride
  • Use with caution in patients with asthma
  • Use with caution in patients with glaucoma
  • Use with caution in patients with enlargement of the prostate gland

Overdose Effects

  • Symptoms: Extreme excitability, seizures, drowsiness, hallucinations
  • Treatment: Appropriate supportive and symptomatic treatment; consider dialysis

Therapeutic Class

  • Anti-emetic drugs

Storage Conditions

  • Keep below 30°C temperature
  • Keep away from light
  • Keep away from moisture
  • Keep out of the reach of children

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