Histin 5 mg/5 ml (Oral Solution)

100 ml bottle: ৳ 15.00

Medicine Details

Category	Details
Generic	Promethazine hydrochloride
Company	Apollo pharmaceutical ltd

Indications

Potent long-acting antihistamine with additional anti-emetic and sedative/calming effects
Symptomatic treatment of allergic conditions of the respiratory tract and skin
Sensitization reactions to drug or foreign proteins, anaphylactic reactions
Adjunct in pre-operative sedation in surgery and obstetrics
Paediatric sedative

Pharmacology

Blocks postsynaptic mesolimbic dopaminergic receptors in the brain
Exhibits strong alpha-adrenergic blocking effect
Depresses the release of hypothalamic and hypophyseal hormones
Competes with histamine for the H1-receptor
Metabolized by the liver

Dosage & Administration

Adults: Initial dose one 25 mg tablet at night; may be increased if necessary
Elderly: No specific dosage recommendations
Children: May be treated more conveniently by the elixir containing 5 mg/5 ml
Antihistamine in allergy:
- Children of 2-5 years: 5-15 mg
- Children of 5-10 years: 10-25 mg
Sedative:
- Children of 2-5 years: 15-20 mg
- Children of 5-10 years: 20-25 mg

Interaction

May enhance the action of anticholinergic agents
May interfere with immunologic urine pregnancy tests
Should be discontinued at least 72 hours before skin tests using allergen extracts

Contraindications

Contraindicated for use in children less than two years of age
Hypersensitivity to promethazine or any of the excipients
Not to be used in patients who are in a coma or suffering from CNS depression
Avoided in patients who have been taking monoamine oxidase inhibitors within the previous 14 days

Side Effects

Nervous system disorders
Immune system disorders
Skin and subcutaneous tissue disorders
Metabolism and nutrition disorders
Gastrointestinal disorders
Eye disorders
Blood and lymphatic system disorders
Renal and urinary disorders
Psychiatric disorders
Cardiac disorders
Vascular disorders
Hepatobiliary disorders
General disorders and administration site conditions

Pregnancy & Lactation

Safety in pregnancy based on epidemiological evidence
Not recommended in the two weeks prior to delivery
Potential benefits to the patient weighed against the possible risk to the fetus
Excreted in breastmilk
Risks of neonatal irritability and excitement

Precautions & Warnings

Avoided in children and adolescents with signs and symptoms suggestive of Reye's syndrome
May thicken or dry lung secretions and impair expectoration
Use with care in patients with severe coronary artery disease
Use with care in patients with narrow angle glaucoma
Use with care in patients with epilepsy
Use with care in patients with hepatic insufficiency
Use with care in patients with renal insufficiency
Caution should be exercised in patients with bladder neck obstruction
Caution should be exercised in patients with pyloro-duodenal obstruction

Overdose Effects

Symptoms of severe overdose are variable. They are characterised in children by various combinations of excitation, ataxia, incoordination, athetosis and hallucinations, while adults may become drowsy and lapse into coma. Convulsions may occur in both adults and children; coma or excitement may precede their occurrence. Tachycardia may develop. Cardiorespiratory depression is uncommon. If the patient is seen soon enough after ingestion, it should be possible to induce vomiting with ipecacuanha despite the antiemetic effect of promethazine; alternatively, gastric lavage may be used. Treatment is otherwise supportive with attention to maintenance of adequate respiratory and circulatory status. Convulsions should be treated with diazepam or other suitable anticonvulsant.

Therapeutic Class

Anti-emetic drugs
Miscellaneous sedatives & hypnotics
Sedating Anti-histamine

Storage Conditions

Protect from light. Do not use later than the date of expiry. Keep all medicines out of the reach of children. To be dispensed only on the prescription of a registered physician