Phenerex 5 mg/5 ml (Oral Solution)

100 ml bottle: ৳ 24.03

Medicine Details

Category Details
Generic Promethazine hydrochloride
Company Jayson pharmaceuticals ltd

Indications

  • Antihistamine
  • Anti-emetic
  • Sedative
  • Allergic conditions of respiratory tract
  • Allergic conditions of skin
  • Sensitization reactions
  • Anaphylactic reactions
  • Allergic rhinitis
  • Urticaria
  • Insomnia
  • Pre-operative sedation
  • Paediatric sedative

Pharmacology

  • Phenothiazine derivative
  • Blocks mesolimbic dopaminergic receptors
  • Strong α-adrenergic blocking effect
  • Competes with histamine for H1-receptor
  • Muscarinic blocking effect
  • Reduces stimuli to brainstem reticular system
  • Well absorbed from gastrointestinal tract
  • Clinical effects within 20 minutes
  • Lasts 4-6 hours
  • Metabolized by the liver

Dosage & Administration

  • Initial dose: 25 mg tablet at night
  • Maximum 75 mg per day for adults
  • Elixir for children
  • Antihistamine dosage for children: 5-25 mg
  • Sedative dosage for children: 15-25 mg

Interactions

  • Enhances anticholinergic agents
  • Interferes with immunologic urine pregnancy tests
  • Inhibits cutaneous histamine response
  • Interaction with tricyclic antidepressants
  • Interaction with sedatives/hypnotics
  • Avoid alcohol during treatment

Contraindications

  • Children under 2 years old
  • Hypersensitivity to promethazine
  • Coma or CNS depression
  • Recent monoamine oxidase inhibitor use

Side Effects

  • Neuroleptic Malignant Syndrome
  • Anticholinergic effects in the elderly
  • Allergic reactions
  • Photosensitivity reaction
  • Anorexia
  • Epigastric discomfort
  • Dry mouth
  • Blurred vision
  • Blood dyscrasias
  • Urinary retention
  • Paradoxical hyperexcitability in children
  • Cardiac effects
  • Hypotension
  • Jaundice
  • Tiredness
  • Risk of abuse

Pregnancy & Lactation

  • Use not recommended unless essential
  • Avoid in the two weeks prior to delivery
  • Excreted in breastmilk
  • Risks of neonatal irritability and excitement
  • Potential benefits vs. risks to fetus

Precautions & Warnings

  • Avoid in Reye’s syndrome symptoms
  • May thicken/dry lung secretions
  • Caution in asthma/bronchitis/bronchiectasis
  • Use with care in coronary artery disease
  • Use with care in narrow angle glaucoma
  • Use with care in epilepsy
  • Use with care in hepatic/renal insufficiency
  • Caution in bladder neck obstruction
  • Caution in pyloro-duodenal obstruction

Overdose Effects

  • Variable symptoms in severe overdose
  • Excitation, ataxia, hallucinations in children
  • Drowsiness, coma in adults
  • Convulsions may occur
  • Possible tachycardia
  • Cardiorespiratory depression uncommon
  • Induce vomiting if seen soon after ingestion
  • Supportive treatment for adequate respiratory/circulatory status
  • Treat convulsions with suitable anticonvulsant

Therapeutic Class

  • Anti-emetic drugs
  • Miscellaneous sedatives & hypnotics
  • Sedating Antihistamine

Storage Conditions

  • Protect from light
  • Do not use after expiry date
  • Keep out of reach of children
  • Dispense only on registered physician's prescription

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