Promestin 5 mg/5 ml (Oral Solution)

60 ml bottle: ৳ 9.94

Medicine Details

Category	Details
Generic	Promethazine hydrochloride
Company	Pharmadesh laboratories ltd

Potent long-acting antihistamine with additional anti-emetic and sedative/calming effects.
Symptomatic treatment of allergic conditions of the respiratory tract and skin.
Sensitization reactions to drug or foreign proteins, anaphylactic reactions.
Sedation for allergic rhinitis, urticaria, and insomnia.
Adjunct in pre-operative sedation in surgery and obstetrics.
Paediatric sedative.

Blocks postsynaptic mesolimbic dopaminergic receptors in the brain.
Exhibits strong α-adrenergic blocking effect.
Competes with histamine for the H1-receptor.
Reduces stimuli to the brainstem reticular system.
Well absorbed from the gastrointestinal tract.
Clinical effects apparent within 20 minutes after oral administration and generally last four to six hours.
Metabolized by the liver to a variety of compounds.

Initial dose one 25 mg tablet at night for adults; may be increased to two or three 25 mg tablets at night if necessary.
Twice or three times daily administration may be necessary in allergic conditions.
Elderly: No specific dosage recommendations.
Children may be treated more conveniently by the elixir containing 5 mg/5 ml.
Specific dosage recommendations for antihistamine in allergy and sedative for children.

May enhance the action of any anticholinergic agent, tricyclic antidepressant, sedative, or hypnotic.
May interfere with immunologic urine pregnancy tests.
Should be discontinued at least 72 hours before the start of skin tests using allergen extracts.

Contraindicated for use in children less than two years of age.
Hypersensitivity to promethazine or any of the excipients.
Not to be used in patients who are in a coma or suffering from CNS depression of any cause.
Avoided in patients who have been taking monoamine oxidase inhibitors within the previous 14 days.

Nervous system disorders: Neuroleptic Malignant Syndrome, anticholinergic effects, confusion, somnolence, dizziness, headaches, extrapyramidal effects, muscle spasm, tic-like movements, neuroleptic malignant syndrome (NMS), high fever, fast heartbeat, agitation, hallucinations.
Immune System Disorders: Allergic reactions including urticaria, rash, pruritus, anaphylaxis, photosensitivity reaction.
Skin and Subcutaneous Tissue Disorders: Photosensitivity reaction.
Metabolism and Nutrition Disorders: Anorexia.
Gastrointestinal Disorders: Epigastric discomfort, dry mouth.
Eye Disorders: Blurred vision.
Blood and Lymphatic System Disorders: Blood dyscrasias incl. hemolytic anemia, agranulocytosis.
Renal and Urinary Disorders: Urinary retention.
Psychiatric Disorders: Anticholinergic effects, paradoxical hyperexcitability, restlessness, nightmares, disorientation.
Cardiac Disorders: Palpitations, arrhythmias.
Vascular disorders: Hypotension.
Hepatobiliary disorders: Jaundice.
General Disorders and Administration Site Conditions: Tiredness.
Advised use and duration of treatment.

Epidemiological evidence for the safety of promethazine in pregnancy.
Animal studies have shown no hazard.
Not recommended in the two weeks prior to delivery due to the risk of irritability and excitement in the neonate.
May cause prolonged neurological disturbances in the infant when given in high doses during late pregnancy.
Excreted in breastmilk, risks of neonatal irritability and excitement.

Avoided in children and adolescents with signs and symptoms suggestive of Reye’s syndrome.
May thicken or dry lung secretions and impair expectoration.
Use with caution in patients with asthma, bronchitis, or bronchiectasis.
Use with care in patients with severe coronary artery disease, narrow angle glaucoma, epilepsy, hepatic or renal insufficiency, bladder neck obstruction, or pyloro-duodenal obstruction.

Symptoms of severe overdose are variable.
Characterised by excitation, ataxia, incoordination, athetosis, hallucinations, drowsiness, and coma.
Convulsions may occur in both adults and children.
Tachycardia may develop.
Supportive treatment with attention to respiratory and circulatory status required.
Convulsions should be treated with diazepam or other suitable anticonvulsant.