Vergon 5 mg (Tablet)
Medicine Details
| Category | Details |
|---|---|
| Generic | Prochlorperazine maleate |
| Company | Opsonin pharma ltd |
| Also available as |
Indications
- Control severe nausea and vomiting caused by radiation therapy, cancer chemotherapy, surgery, and other conditions
- Relieving nausea, vomiting, and attacks of dizziness or spinning sensations (vertigo) associated with Meniere's disease and other inner ear disorders
Pharmacology
Dopamine & histamine antagonist; antiemetic activity due to blockade of histamine H and dopamine D2 neurotransmitter receptors
Dosage & Administration
- Antiemetic:
- Children:
- 10-14 kg: 2.5 mg every 12-24 hours as needed; maximum: 7.5 mg/day
- 15-18 kg: 2.5 mg every 8-12 hours as needed; maximum: 10 mg/day
- 19-39 kg: 2.5 mg every 8 hours or 5 mg every 12 hours as needed; maximum: 15 mg/day
- Adults: 5-10 mg 3-4 times/day; usual maximum: 40 mg/day
- Children:
- Antipsychotic:
- Children:
- 2-12 years: 2.5 mg 2-3 times/day
- Maximum daily dose of 20 mg for 2-5 years and 25 mg for 6-12 years
- Adults: 5-10 mg 3-4 times/day; doses up to 150 mg/day may be required in some patients
- Children:
- Nonpsychotic anxiety:
- Adults: Usual dose: 15-20 mg/day in divided doses; do not give doses >20 mg/day or for longer than 12 weeks
- Elderly: Initial: 2.5-5 mg 1-2 times/day; increase dose at 4 to 7 day intervals by 2.5-5 mg/day; maximum daily dose should probably not exceed 75 mg
Interaction
- Alcohol, barbiturate & other sedatives may increase the CNS depressant action
- Some drugs like Antacids, antiparkinson's drug, lithium may interfere the absorption of Vergon
- Vergon may interfere with the plasma concentration of Propranolol and Phenobarbital
Contraindications
Hypersensitivity to prochlorperazine or any component of the formulation, severe CNS depression; coma; should not be used in children <2 years of age or <10 kg
Side Effects
- Drowsiness
- Jaw, neck, and back muscle spasms
- Fine worm-like tongue movements
- Rhythmic face, mouth, or jaw movements
- Slow or difficult speech
- Difficulty swallowing
- Restlessness and pacing
- Tremors
- Shuffling walk
- Skin rash
- Yellowing of the skin or eyes
Pregnancy & Lactation
No evidence of adverse effects of this drug has been reported during pregnancy & lactation
Precautions & Warnings
Caution should be taken while performing tasks that require alertness, such as driving or using machinery; use of alcohol can cause extreme drowsiness; increased sensitivity to sunlight; reduced sweating making it more susceptible to heatstroke
Overdose Effects
Deep sleep, coma, extrapyramidal symptoms, abnormal involuntary muscle movements, hypotension
Therapeutic Class
- Anti vertigo drugs
- Anti-emetic drugs
Storage Conditions
Store below 30°C; Protect from light and moisture; Keep out of the reach of children