Menaril 8 mg (Tablet)
Unit Price: ৳ 3.00 (10 x 10: ৳ 300.00)
Strip Price: ৳ 30.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Betahistine dihydrochloride |
| Company | Incepta pharmaceuticals ltd |
| Also available as |
Indications
- Meniere's disease
- Meniere-like syndromes
- Vertigo
- Tinnitus
- Progressive loss of hearing
- Nausea
- Vomiting
Description
- Histamine analog
- Relieves symptoms of Meniere's disease
- Improves circulation in the inner ear
- Reduces pressure on the membranous labyrinth
Pharmacology
- Multifactorial action
- Acts as histamine H1-receptor agonist
- Causes vasodilatory effect
- Reduces endolymphatic pressure
- Increases vestibulocochlear blood flow
- Acts as histamine H3-receptor antagonist
Dosage & Administration
- Initial oral treatment: 8-16mg three times daily
- Maintenance doses: 24-48 mg daily
- Not to exceed 48mg daily
- Dosage adjustment for individual patient needs
- No data available for hepatic impairment
- No data available for renal impairment
- Limited data in the elderly
- Not recommended for children and adolescents below age 18
Interaction
- No proven hazardous interactions
- Case report of interaction with ethanol and a compound containing pyrimethamine with dapsone
- Potentiation of betahistine with salbutamol
- Mutual attenuation of effect with concurrent administration of H1 antagonists
Contraindications
- Phaeochromocytoma
- Hypersensitivity to the active substance
Side Effects
- Generally well tolerated
- Gastrointestinal disturbances
- Headache
- Rashes
- Pruritus
Pregnancy & Lactation
- Safety in human pregnancy not completely established
- No known teratogenic effect in animals
- Caution in pregnancy
- Excretion in breast milk
- Toxicity to neonate not known
Precautions & Warnings
- Caution in peptic ulcer or history of peptic ulceration
- Caution in bronchial asthma
- Caution in urticaria, rashes, or allergic rhinitis
- Caution in severe hypotension
- Not for patients with rare hereditary problems of galactose intolerance
- Effects on ability to drive and use machines
Overdose Effects
- Nausea
- Vomiting
- Dyspepsia
- Ataxia
- Seizures
- Serious complications in cases of intentional overdose
- No specific antidote
- Gastric lavage and symptomatic treatment recommended
Therapeutic Class
- Drugs used in Meniere's disease
Storage Conditions
- Keep below 30°C temperature
- Away from light & moisture
- Keep out of the reach of children