Maxocol 10 mg (Tablet)

Unit Price: ৳ 0.34 (100's pack: ৳ 34.00)

Medicine Details

Category Details
Generic Metoclopramide hydrochloride
Company Medimet pharmaceuticals ltd
Also available as
Maxocol 5 mg syrup

Indications

  • Relief of symptoms in adults with acute and recurrent diabetic gastroparesis
  • Treatment for symptomatic, documented gastroesophageal reflux in adults
  • The Prevention of Nausea and Vomiting Associated with Emetogenic Cancer Chemotherapy
  • The Prevention of Postoperative Nausea and Vomiting
  • Small Bowel Intubation facilitation in adults and pediatric patients
  • Stimulation of gastric emptying and intestinal transit of barium for radiological examination

Pharmacology

  • Blocks dopamine receptors
  • Blocks serotonin receptors in chemoreceptor trigger zone of the CNS
  • Enhances the response to acetylcholine of tissue in the upper GI tract
  • Accelerates gastric emptying without stimulating gastric, biliary, or pancreatic secretions
  • Increases lower esophageal sphincter tone

Dosage & Administration

  • Adults less than 65 years of age: Recommended dosage is 1 spray (15 mg) in one nostril, 30 minutes before each meal and at bedtime (max of 4 sprays daily) for 2 to 8 weeks
  • Adults 65 years of age and older: Metoclopramide is not recommended as initial therapy, but can be used as an alternative at a stable dosage
  • Continuous administration: 10 to 15 mg, 30 minutes before each meal and at bedtime (max of 60 mg per day) for 4 to 12 weeks
  • Intermittent administration: Single doses up to 20 mg prior to provoking situation
  • Diabetic Gastroparesis: 10 mg, 30 minutes before each meal and at bedtime (max of 40 mg per day) for 2 to 8 weeks

Contraindications

  • Patients with a history of tardive dyskinesia or a dystonic reaction to metoclopramide
  • When stimulation of gastrointestinal motility might be dangerous
  • In patients with pheochromocytoma or other catecholamine-releasing paragangliomas
  • In patients with epilepsy
  • In patients with hypersensitivity to metoclopramide

Side Effects

  • Most common adverse reactions (≥5%) are: dysgeusia, headache, and fatigue

Pregnancy & Lactation

  • Pregnancy Category B: Reproduction studies demonstrated no impairment of fertility or significant harm to the fetus due to metoclopramide, but there are no adequate and well-controlled studies in pregnant women
  • Excreted in human milk, caution should be exercised when administered to a nursing mother

Precautions & Warnings

  • Avoid concomitant use of other drugs known to cause TD/EPS/NMS
  • Avoid use in patients with Parkinson’s Disease
  • Discontinue if symptoms of TD, EPS, or NMS occur
  • Avoid use in patients with depression and suicidal ideation/suicide

Therapeutic Class

  • Anti-emetic drugs
  • Prokinetic drugs

Storage Conditions

  • Store between 20-25°C
  • Protect from light

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