Anset 4 mg (Tablet)

Indications

• Prevention of nausea and vomiting associated with emetogenic cancer chemotherapy
• Prevention and treatment of post-operative nausea and vomiting
• Prevention of radiotherapy-induced nausea and vomiting

Dosage

• 8 mg tablet/orodispersible tablet for adults and pediatric patients
• 4 mg orodispersible tablet for adults and pediatric patients
• Injection dose for adults and pediatric patients
• Oral solution dosage for adults/greiatric/child of 12 years or over
• Recommended oral dosage for radiotherapy induced nausea and vomiting
• Film dosage for different conditions and age groups

Administration

• Tear the pouch carefully along the edge tear mark
• Put the Ondansetron film on top of your tongue and let it dissolve within 20 seconds
• Do not chew or swallow the film whole
• Swallow after the film dissolves. It can be swallowed with or without liquid
• Wash hands after taking the film

Interaction

• Anset does not induce or inhibit the cytochrome P-450 drug-metabolizing enzyme system of the liver
• Inducers or inhibitors of these enzymes may change the clearance of Anset

Contraindications

• Contraindicated in patients known to have hypersensitivity to the drug or any of its components
• Concomitant use of apomorphine

Side Effects

• Frequently reported adverse events: headache, constipation, diarrhea, rash, flushing or warmth, hiccups, liver enzyme abnormalities
• Rare cases of: anaphylaxis, brochospasm, tachycardia, angina, hypokalemia, shortness of breath

Pregnancy & Lactation

• Carcinogenic effects not seen in 2-year studies in rats and mice with oral Ondansetron doses
• Ondansetron was not mutagenic in standard tests for mutagenicity
• Reproduction studies with Ondansetron in pregnant rats and rabbits have revealed no evidence of impaired fertility or harm to the fetus

Precautions & Warnings

• Hypersensitivity reactions reported in patients who have exhibited hypersensitivity to other selective 5-HT3 receptor antagonists
• Anset is not a drug that stimulates gastric or intestinal peristalsis
• Should not be used instead of nasogastric suction

Therapeutic Class

• Anti-emetic drugs

Storage Conditions

• Store at temperature not exceeding 30°C in a dry place
• Protect from light and moisture

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