Anset 16 mg (Suppository)
Unit Price: ৳ 15.00 (2 x 5: ৳ 150.00)
Medicine Details
| Category | Details |
|---|---|
| Generic | Ondansetron |
| Company | Opsonin pharma ltd |
| Also available as |
Indications
- Prevention of nausea and vomiting associated with initial and repeat courses of emetogenic cancer chemotherapy
- Prevention and treatment of post-operative nausea and vomiting
- Prevention of radiotherapy-induced nausea and vomiting
Description
- Orally dissolving film designed to be applied on top of the tongue
- Dissolves within 20 seconds
- Swallowed with saliva
- No water required for dissolution or swallowing
- Active ingredient: Anset base
Pharmacology
- Potent and highly selective 5HT3 receptor-antagonist
- Mode of action not fully known
- Blocks initiation of vomiting reflex
- Antagonism of 5HT3 receptors in peripheral and central nervous system
- Mechanisms of action in post-operative nausea and vomiting not known
Dosage
- Multiple dosage forms available (tablets, orodispersible tablets, injection, oral solution, oral soluble film)
- Dosage varies for adults, pediatric patients, and specific conditions
- Dosage adjustments for highly emetogenic and moderately emetogenic cancer chemotherapy
- Different dosages for radiotherapy-induced and postoperative nausea and vomiting
Administration
- Step-by-step instructions for administration of oral soluble film
- Emphasizes swallowing after film dissolves
- Instructions for washing hands after administration
Interaction
- Metabolized by hepatic cytochrome P-450 drug-metabolizing enzymes
- Potential for drug interactions altering clearance and half-life
Contraindications
- Contraindicated in patients with hypersensitivity to the drug or its components
- Concomitant use of apomorphine
Side Effects
- Frequently reported adverse events include headache, constipation, and diarrhea
- Rare cases of anaphylaxis, brochospasm, tachycardia, angina, hypokalemia, and shortness of breath
Pregnancy & Lactation
- No evidence of impaired fertility or harm to fetus in animal studies
- Exercise caution in breastfeeding women
Precautions & Warnings
- Hypersensitivity reactions reported
- Not a drug that stimulates gastric or intestinal peristalsis
- Caution in patients following abdominal surgery or with chemotherapy-induced nausea and vomiting
Use in Special Populations
- Dosage adjustment not needed for patients with impaired renal function
- Dosage adjustment provided for patients with impaired hepatic function
- Little information available about dosage in pediatric patients 4 years of age or younger
Therapeutic Class
- Anti-emetic drugs
Storage Conditions
- Store at temperature not exceeding 30°C
- Keep in a dry place
- Protection from light and moisture required