Emeren 8 mg/4 ml (IM/IV Injection)

4 ml ampoule: ৳ 32.00 (1 x 5: ৳ 160.00)

Medicine Details

Category Details
Generic Ondansetron
Company Renata limited
Also available as
Emeren 4 mg tablet Emeren 8 mg tablet Emeren 4 mg oral solution

Indications

  • Prevention of nausea and vomiting associated with initial and repeat courses of emetogenic cancer chemotherapy
  • Prevention and treatment of post-operative nausea and vomiting
  • Prevention of radiotherapy-induced nausea and vomiting

Description

  • Orally dissolving film designed to be applied on top of the tongue
  • Dissolves within 20 seconds
  • Active ingredient: Emeren base
  • Racemic form of Emeren
  • Selective blocking agent of the serotonin 5-HT3 receptor type
  • Empirical formula: C18H19N3O
  • Molecular weight: 293.3

Pharmacology

  • Potent, highly selective 5HT3 receptor-antagonist
  • Precise mode of action not known
  • Blocks initiation of vomiting reflex
  • Antagonism of 5HT3 receptors in the peripheral and central nervous system
  • Mechanism of action in post-operative nausea and vomiting not known

Dosage

  • Multiple dosing options for adults and pediatric patients
  • Dosage varies based on the type of nausea and vomiting (chemotherapy-induced, radiotherapy-induced, postoperative)
  • Oral solution and oral soluble film options available
  • Dosage adjustment for patients with impaired renal function and impaired hepatic function

Administration

  • Step-by-step guide for administering oral soluble film
  • Film dissolves within 20 seconds
  • No need for water to aid dissolution or swallowing

Interaction

  • Metabolized by hepatic cytochrome P-450 drug-metabolizing enzymes
  • Effects on clearance and half-life if used with inducers or inhibitors of these enzymes

Contraindications

  • Hypersensitivity to the drug or any of its components
  • Concomitant use of apomorphine

Side Effects

  • Frequently reported adverse events: headache, constipation, diarrhea
  • Mild or moderate nature of majority of adverse events
  • Rare cases of anaphylaxis, brochospasm, tachycardia, angina, hypokalemia, shortness of breath
  • No evidence of extrapyramidal reactions

Pregnancy & Lactation

  • No evidence of carcinogenic effects in rats and mice
  • No mutagenicity in standard tests
  • No effect on fertility or general reproduction performance in rats
  • No adequate and well-controlled studies in pregnant women
  • Excreted in the breast milk of rats

Precautions & Warnings

  • Reported hypersensitivity reactions in some patients
  • Not a drug that stimulates gastric or intestinal peristalsis
  • Should not be used instead of nasogastric suction
  • May mask a progressive ileus and/or gastric distension

Use in Special Populations

  • Dosage adjustment for patients with impaired hepatic function
  • Limited information about dosage in pediatric patients 4 years of age or younger

Therapeutic Class

  • Anti-emetic drugs

Storage Conditions

  • Store at temperature not exceeding 30°C
  • Store in a dry place
  • Protect from light and moisture

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