Emistat 8 mg/4 ml (IM/IV Injection)

4 ml ampoule: ৳ 32.00 (2 x 5: ৳ 320.00)

Medicine Details

Category Details
Generic Ondansetron
Company Healthcare pharmaceuticals ltd
Also available as
Emistat ft 4 mg flash tablet Emistat 8 mg tablet Emistat 4 mg oral solution Emistat ft 8 mg flash tablet

Title and Categories

  • Emistat Oral Soluble Film
  • Anti-emetic drugs

Dimensions

  • Orally dissolving film
  • Molecular weight 293.3

Color Options

Functions

  • Prevention of nausea and vomiting associated with chemotherapy
  • Treatment of post-operative nausea and vomiting
  • Prevention of radiotherapy-induced nausea and vomiting

Materials

  • Emistat base

Technical Specifications

  • Empirical formula: C18H19N3O

Design Elements

Usability Features

  • Does not require water for dissolution or swallowing

Dosage Options

  • 8 mg orodispersible tablet
  • 4 mg orodispersible tablet
  • Injection

Chemotherapy-Induced Nausea and Vomiting Dosage

  • Adults: Three 0.15 mg/kg doses, up to a maximum of 16 mg per dose

Radiation-Induced Nausea and Vomiting Dosage

  • Adults: 8 mg tablet/orodispersible tablet initial dose and 8 mg orally every 8 hours for up to 5 days after treatment
  • Pediatrics (>40 kg): Injection: 4 mg
  • Pediatrics (40 kg): Injection: 0.1 mg/kg

Postoperative Nausea and Vomiting Dosage

  • Adults: 16 mg given as two 8 mg tablets
  • Pediatrics: Injection 4 mg, 0.1 mg/kg for those over 40 kg
  • Highly emetogenic cancer chemotherapy: 30 ml (24 mg) oral solution administered 30 minutes before chemotherapy

Administration Process

  • Tear the pouch carefully along the edge tear mark
  • Place the film on top of the tongue where it will dissolve within 20 seconds
  • Do not chew or swallow the film whole
  • Swallow after the film dissolves

Interaction

  • Metabolized by hepatic cytochrome P-450 drug-metabolizing enzymes
  • Inducers or inhibitors of these enzymes may change the clearance and half-life of Emistat

Contraindications

  • Hypersensitivity to the drug or any of its components
  • Concomitant use of apomorphine

Side Effects

  • Headache
  • Constipation
  • Diarrhea
  • Rash in chemotherapy-induced nausea and vomiting
  • Sensation of flushing or warmth
  • Hiccups
  • Liver enzyme abnormalities
  • Rare cases of anaphylaxis
  • Brochospasm
  • Tachycardia
  • Angina
  • Hypokalemia
  • Shortness of breath

Pregnancy & Lactation

  • No evidence of impaired fertility or harm to the fetus due to Ondansetron
  • Excreted in the breast milk of rats
  • Caution advised for nursing women

Precautions & Warnings

  • Hypersensitivity reactions reported
  • Not a drug that stimulates gastric or intestinal peristalsis
  • Should not be used instead of nasogastric suction

Use in Special Populations

  • Dosage adjustment for patients with impaired renal function
  • Dosage adjustment for patients with impaired hepatic function
  • Little information available about dosage in pediatric patients 4 years of age or younger
  • No dosage adjustment needed in patients over the age of 65

Therapeutic Class

  • Anti-emetic drugs

Storage Conditions

  • Store at temperature not exceeding 30ºC
  • Dry place
  • Protect from light and moisture

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