Emiston 8 mg/4 ml (IM/IV Injection)

4 ml ampoule: ৳ 27.00 (1 x 5: ৳ 135.00)

Medicine Details

Category Details
Generic Ondansetron
Company Ibn sina pharmaceuticals ltd
Also available as
Emiston 8 mg tablet Emiston 4 mg oral solution

Indications

  • Prevention of nausea and vomiting associated with initial and repeat courses of emetogenic cancer chemotherapy
  • Prevention and treatment of post-operative nausea and vomiting
  • Prevention of radiotherapy-induced nausea and vomiting

Description

  • Orally dissolving film designed to be applied on top of the tongue
  • Dissolves within 20 seconds
  • Active ingredient: Emiston base
  • Empirical formula: C18H19N3O
  • Molecular weight: 293.3

Pharmacology

  • Potent, highly selective 5HT3 receptor-antagonist
  • Precise mode of action is not known
  • Blocks initiation of vomiting reflex
  • Acts on neurons in peripheral and central nervous system

Dosage

  • Different dosages for adults and pediatric patients
  • Dosage adjustment for different types of nausea and vomiting
  • Oral solution and oral soluble film options
  • Specific dosage for chemotherapy and radiotherapy-induced nausea and vomiting

Administration

  • Step by step instructions for administration of oral soluble film
  • Emphasis on not chewing or swallowing the film whole

Interaction

  • Emiston does not induce or inhibit the cytochrome P-450 drug-metabolizing enzyme system
  • Metabolized by hepatic cytochrome P-450 drug-metabolizing enzymes

Contraindications

  • Contraindicated in patients known to have hypersensitivity to the drug or any of its components
  • Concomitant use of apomorphine

Side Effects

  • Frequently reported adverse events: headache, constipation, diarrhea, rash, sensation of flushing or warmth, hiccups, liver enzyme abnormalities
  • Rare cases of anaphylaxis, bronchospasm, tachycardia, angina, hypokalemia, shortness of breath
  • No evidence of extrapyramidal reactions

Pregnancy & Lactation

  • No evidence of carcinogenic effects in animal studies
  • No mutagenic effects observed
  • No impairment to fertility or harm to fetus observed
  • No adequate and well-controlled studies in pregnant women
  • Excreted in the breast milk of rats
  • Caution advised when administered to nursing women

Precautions & Warnings

  • Reported hypersensitivity reactions
  • Not a drug that stimulates gastric or intestinal peristalsis
  • Should not be used instead of nasogastric suction
  • May mask a progressive ileus and/or gastric distension

Use in Special Populations

  • Same dosage recommendation for patients with impaired renal function
  • Specific dosage recommendation for severe hepatic impairment
  • Limited information available about dosage in pediatric patients 4 years of age or younger
  • No dosage adjustment needed in patients over the age of 65

Therapeutic Class

  • Anti-emetic drugs

Storage Conditions

  • Store at temperature not exceeding 30°C
  • Dry place
  • Protection from light and moisture

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