Onaseron 8 mg/4 ml (IM/IV Injection)
4 ml ampoule: ৳ 25.00 (1 x 5: ৳ 125.00)
Medicine Details
| Category | Details |
|---|---|
| Generic | Ondansetron |
| Company | Incepta pharmaceuticals ltd |
| Also available as |
Title
- Onaseron Oral Soluble Film
Categories
- Pharmaceuticals
- Medication
- Anti-emetic drugs
Dosage Options
- 8 mg tablet
- 4 mg orodispersible tablet
- Injection
- Oral Solution
- Oral Soluble Film
Color Options
- Transparent
Function
- Prevention of nausea
- Prevention of vomiting
- Treatment of post-operative nausea and vomiting
- Prevention of radiotherapy-induced nausea and vomiting
Active Ingredient
- Onaseron base
- Selective blocking agent of the serotonin 5-HT3 receptor type
Empirical Formula
- C18H19N3O
Molecular Weight
- 293.3
Dissolving Time
- Within 20 seconds
Method of Administration
- Orally dissolving film applied on top of the tongue
Dosage Administration Steps
- Tear the pouch carefully
- Put the film on the tongue
- Do not chew or swallow the film whole
- Swallow after the film dissolves
- Wash hands after administration
Pharmacology
- Selective 5HT3 receptor-antagonist
- Blocks 5HT3 receptors in peripheral and central nervous system
- Antagonizes 5HT3 receptors on neurons
- Mechanism of action in post-operative nausea and vomiting not known
Interaction
- Metabolized by hepatic cytochrome P-450 drug-metabolizing enzymes
- Inducers or inhibitors of these enzymes may change clearance and half-life
Contraindications
- Hypersensitivity to the drug or its components
- Concomitant use of apomorphine
Side Effects
- Headache
- Constipation
- Diarrhea
- Rash
- Sensation of flushing or warmth
- Hiccups
- Liver enzyme abnormalities
- Anaphylaxis (rare)
- Brochospasm (rare)
- Tachycardia (rare)
- Angina (rare)
- Hypokalemia (rare)
- Shortness of breath (rare)
Pregnancy & Lactation
- No evidence of impaired fertility or harm to fetus in animal studies
- Excreted in breast milk of rats
- Caution advised during nursing
Precautions & Warnings
- Hypersensitivity reactions reported
- Not a drug that stimulates gastric or intestinal peristalsis
- Should not be used instead of nasogastric suction
- May mask a progressive ileus and/or gastric distension
Special Population Dosage
- Dosage same for patients with impaired renal function
- Single maximal daily dose for severe hepatic impairment
- Limited information for patients under 4 years of age
Therapeutic Class
- Anti-emetic drugs
Storage Conditions
- Store at temperature not exceeding 30°C
- Dry place
- Protect from light and moisture