Onasia 8 mg (Tablet)

Unit Price: ৳ 10.00 (3 x 10: ৳ 300.00)
Strip Price: ৳ 100.00

Medicine Details

Category Details
Generic Ondansetron
Company Orion pharma ltd
Also available as
Onasia 8 mg injection Onasia 4 mg oral solution

Indications

  • Prevention of nausea and vomiting associated with initial and repeat courses of emetogenic cancer chemotherapy
  • Prevention and treatment of post-operative nausea and vomiting
  • Prevention of radiotherapy-induced nausea and vomiting

Description

  • Oral soluble film designed to be applied on top of the tongue
  • Dissolves within 20 seconds
  • Swallowed with saliva
  • Does not require water to aid dissolution or swallowing
  • Active ingredient: Ondansetron base
  • Empirical formula: C18H19N3O

Pharmacology

  • Potent, highly selective 5HT3 receptor-antagonist
  • Precise mode of action not fully known
  • Blocks 5HT3 receptors in peripheral and central nervous system

Dosage

  • Different doses for adults, pediatric patients, geriatric patients, and children
  • Doses for chemotherapy-induced, radiotherapy-induced, and postoperative nausea and vomiting
  • Different dosages for oral solution, oral soluble film, and injection
  • Dosage adjustments for different patient populations

Administration

  • Oral soluble film administration steps provided
  • No need for water during administration

Interaction

  • Metabolized by hepatic cytochrome P-450 drug-metabolizing enzymes
  • Inducers or inhibitors of these enzymes may change clearance and half-life
  • No dosage adjustment recommended for patients on certain drugs

Contraindications

  • Hypersensitivity to the drug or any of its components
  • Concomitant use of apomorphine

Side Effects

  • Frequently reported adverse events: headache, constipation, diarrhea, rash
  • Majority of adverse events are mild or moderate in nature
  • Rare cases of anaphylaxis, brochospasm, tachycardia, angina, hypokalemia, shortness of breath
  • No evidence of extrapyramidal reactions

Pregnancy & Lactation

  • No evidence of carcinogenic effects in animal studies
  • No evidence of mutagenicity in standard tests
  • No adverse effects on fertility or reproduction performance in animal studies
  • Caution recommended when administered to nursing women

Precautions & Warnings

  • Reported hypersensitivity reactions in patients with hypersensitivity to other 5-HT3 receptor antagonists
  • Not a drug that stimulates gastric or intestinal peristalsis
  • Should not be used instead of nasogastric suction
  • May mask a progressive ileus and/or gastric distension

Use in Special Populations

  • Dosage adjustment not needed for patients with impaired renal function
  • Recommended single maximal daily dose for severe hepatic impairment
  • Limited information available for pediatric patients 4 years of age or younger

Therapeutic Class

  • Anti-emetic drugs

Storage Conditions

  • Store at temperature not exceeding 30°C
  • Store in a dry place
  • Protect from light and moisture

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