Onasia 8 mg/4 ml (IM/IV Injection)
4 ml ampoule: ৳ 25.08 (1 x 5: ৳ 125.40)
Medicine Details
| Category | Details |
|---|---|
| Generic | Ondansetron |
| Company | Orion pharma ltd |
| Also available as |
Indications
- Prevention of nausea and vomiting associated with initial and repeat courses of emetogenic cancer chemotherapy
- Prevention and treatment of post-operative nausea and vomiting
- Prevention of radiotherapy-induced nausea and vomiting
Dosage
- Available in 8 mg and 4 mg tablets/orodispersible tablets
- Injection available for intravenous use
- Dosage depends on age and type of nausea and vomiting, ranging from 4 mg to 30 ml (24 mg) oral solution
Mode of Action
- Acts as a highly selective 5HT3 receptor antagonist
- Blocks initiation of vomiting reflex by activating vagal afferents
- Antagonizes 5HT3 receptors in peripheral and central nervous system
Administration
- Oral soluble film designed to dissolve within 20 seconds when applied on tongue
- No water required for dissolution or swallowing
- Instructions for proper administration provided
Interaction
Metabolized by hepatic cytochrome P-450 drug-metabolizing enzymes
Contraindications
- Hypersensitivity to the drug or any of its components
- Concomitant use of apomorphine
Side Effects
- Frequently reported adverse events: headache, constipation, diarrhea
- Rare cases of anaphylaxis, tachycardia, chest pain reported
Pregnancy & Lactation
- No evidence of impaired fertility or harm to the fetus in animal studies
- Excreted in breast milk of rats, caution advised during nursing
Precautions & Warnings
- Caution in patients with hypersensitivity to other 5-HT3 receptor antagonists
- Not a drug that stimulates gastric or intestinal peristalsis
- Should not be used in place of nasogastric suction
Special Populations
- Dosage adjustment for patients with impaired renal function same as general population
- Dosage adjustment in severe hepatic impairment recommended
- Limited information about dosage for pediatric patients 4 years of age or younger
Therapeutic Class
Anti-emetic drugs
Storage Conditions
Store at temperature not exceeding 30°C in a dry place, protect from light and moisture