Onatron 4 mg/5 ml (Oral Solution)
50 ml bottle: ৳ 45.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Ondansetron |
| Company | Novelta bestway pharma ltd |
| Also available as |
Indications
- Prevention of nausea and vomiting associated with initial and repeat courses of emetogenic cancer chemotherapy
- Prevention and treatment of post-operative nausea and vomiting
- Prevention of radiotherapy-induced nausea and vomiting
Description
- Oral soluble film designed for application on top of the tongue
- Dissolves within 20 seconds
- Contains Onatron base - a selective blocking agent of the serotonin 5-HT3 receptor type
Pharmacology
- Potent, highly selective 5HT3 receptor-antagonist
- Precise mode of action in control of nausea and vomiting is not known
- Blocks initiation of vomiting reflex by activating vagal afferents via 5HT3 receptors
Dosage
- Variety of dosages for adults, pediatric patients, and different chemotherapy or radiotherapy cases
- Oral solution and oral soluble film dosages specified
Administration
- Steps for administration of oral soluble film
- Tear the pouch, place the film on top of the tongue, let it dissolve, and swallow
Interaction
- Metabolized by hepatic cytochrome P-450 drug-metabolizing enzymes
- Inducers or inhibitors of these enzymes may change clearance and half-life of Onatron
Contraindications
- Contraindicated in patients with hypersensitivity to the drug or any of its components
- Concomitant use of apomorphine
Side Effects
- Frequently reported adverse events such as headache, constipation, and diarrhea
- Rare cases of anaphylaxis, brochospasm, tachycardia, angina, hypokalemia, shortness of breath
Pregnancy & Lactation
- Carcinogenic effects not seen in 2-year studies in rats and mice
- No adequate and well-controlled studies in pregnant women
- Excreted in the breast milk of rats
Precautions & Warnings
- Hypersensitivity reactions reported in patients with hypersensitivity to other selective 5-HT3 receptor antagonists
- Not a drug that stimulates gastric or intestinal peristalsis
- Caution required when administered to nursing women
Use in Special Populations
- Dosage adjustments for patients with impaired renal or hepatic function
- Limited information available about dosage in pediatric patients 4 years of age or younger
Therapeutic Class
- Anti-emetic drugs
Storage Conditions
- Store at temperature not exceeding 30°C in a dry place
- Protect from light and moisture