Oncodex 4 mg (Tablet)
Unit Price: ৳ 4.53 (3 x 10: ৳ 136.00)
Strip Price: ৳ 45.33
Medicine Details
| Category | Details |
|---|---|
| Generic | Ondansetron |
| Company | Jayson pharmaceuticals ltd |
| Also available as |
Product Title
- Oncodex Oral Soluble Film
Categories
- Anti-emetic drugs
Description
- Orally dissolving film designed to be applied on top of the tongue
- Dissolves within 20 seconds
- Swallowed with saliva
- No water required for dissolution
- Active ingredient: Ondansetron base
- Empirical formula: C18H19N3O
- Molecular weight: 293.3
Indications
- Prevention of nausea and vomiting associated with emetogenic cancer chemotherapy
- Prevention and treatment of post-operative nausea and vomiting
- Prevention of radiotherapy-induced nausea and vomiting
Pharmacology
- Potent, highly selective 5HT3 receptor-antagonist
- Precise mode of action in the control of nausea and vomiting not known
- Blocks initiation of vomiting reflex
- Antagonizes 5HT3 receptors in peripheral and central nervous system
Dosage
- Different dosages for adults, pediatric patients, and geriatric patients
- Variety of dosage forms - tablet, orodispersible tablet, injection, oral solution
- Dosages based on emetogenic potential and indication
- Specific recommended dosages for different types of chemotherapy and radiotherapy
Administration
- Instructions for administering the Oral Soluble Film - tear pouch, place on tongue, do not chew, swallow after dissolved, wash hands after administration
Interaction
- Metabolized by hepatic cytochrome P-450 drug-metabolizing enzymes
- No dosage adjustment recommended for patients on drugs that induce or inhibit these enzymes
Contraindications
- Hypersensitivity to the drug or any of its components
- Concomitant use of apomorphine
Side Effects
- Frequently reported adverse events: headache, constipation, diarrhea
- Occasional events: rash, flushing, hiccups, liver enzyme abnormalities
- Rare cases of anaphylaxis, brochospasm, tachycardia, angina, hypokalemia, shortness of breath
Pregnancy & Lactation
- No evidence of carcinogenic or mutagenic effects in animal studies
- No adequate and well-controlled studies in pregnant women
- Excreted in breast milk of rats
- Caution advised when administering to nursing women
Precautions & Warnings
- Hypersensitivity reactions reported in patients with hypersensitivity to selective 5-HT3 receptor antagonists
- Not a drug that stimulates gastric or intestinal peristalsis
- Caution in patients with abdominal surgery or chemotherapy-induced nausea and vomiting
Pediatric Uses
- Little information available about dosage in pediatric patients 4 years of age or younger
- Dosage adjustment not needed in patients over the age of 65
Therapeutic Class
- Anti-emetic drugs
Storage Conditions
- Store at temperature not exceeding 30°C
- Dry place
- Protect from light and moisture