Onsat 8 mg/4 ml (IM/IV Injection)

4 ml ampoule: ৳ 25.00 (1 x 5: ৳ 125.00)

Medicine Details

Title

  • Onsat Oral Soluble Film

Categories

  • Medicines
  • Pharmaceuticals
  • Anti-emetic drugs

Description

  • A serotonin subtype 3 (5-HT3) receptor antagonist
  • Orally dissolving film
  • Contains Onsat base - a selective blocking agent of the serotonin 5-HT3 receptor type
  • Molecular weight: 293.3

Dimensions

  • Film size: Small and thin

Color options

  • Clear film

Functions

  • Prevention of nausea and vomiting associated with cancer chemotherapy
  • Prevention and treatment of post-operative nausea and vomiting
  • Prevention of radiotherapy-induced nausea and vomiting

Materials

  • Onsat base
  • Cellulose-based film

Technical specifications

  • Active ingredient: Onsat base
  • Empirical formula: C18H19N3O
  • Molecular weight: 293.3
  • Dissolves within 20 seconds when placed on the tongue

Design elements

  • Oral soluble film
  • Packaged in individual pouches

Usability features

  • Does not require water for dissolution or swallowing
  • Convenient for patients who have difficulty swallowing tablets or capsules

Dosage

  • 8 mg and 4 mg tablets or orodispersible tablets
  • Injections available
  • Dosage varies for different age groups and indications

Administration

  • Oral administration
  • Film is placed on the tongue and allowed to dissolve

Interaction

  • Metabolized by hepatic cytochrome P-450 drug-metabolizing enzymes
  • Potential for drug interactions with inducers or inhibitors of these enzymes

Contraindications

  • Hypersensitivity to the drug or any of its components
  • Concomitant use of apomorphine

Side effects

  • Common adverse events: Headache, constipation, diarrhea, rash
  • Rare adverse events: Anaphylaxis, brochospasm, tachycardia, hypokalemia
  • No evidence of extrapyramidal reactions

Pregnancy and lactation

  • No evidence of carcinogenic effects or mutagenicity
  • Caution when administered to nursing women

Precautions and warnings

  • Patients who have exhibited hypersensitivity to other selective 5-HT3 receptor antagonists may experience hypersensitivity reactions
  • Not to be used instead of nasogastric suction
  • May mask a progressive ileus and/or gastric distension

Special populations

  • Same dosage recommendation for patients with impaired renal function
  • Recommended single daily dose for patients with severe hepatic impairment

Therapeutic class

  • Anti-emetic drugs

Storage conditions

  • Store at temperature not exceeding 30°C in a dry place
  • Protect from light and moisture

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