Onsat 8 mg/4 ml (IM/IV Injection)
4 ml ampoule: ৳ 25.00 (1 x 5: ৳ 125.00)
Medicine Details
Category | Details |
---|---|
Generic | Ondansetron |
Company | Beximco pharmaceuticals ltd |
Also available as |
Title
- Onsat Oral Soluble Film
Categories
- Medicines
- Pharmaceuticals
- Anti-emetic drugs
Description
- A serotonin subtype 3 (5-HT3) receptor antagonist
- Orally dissolving film
- Contains Onsat base - a selective blocking agent of the serotonin 5-HT3 receptor type
- Molecular weight: 293.3
Dimensions
- Film size: Small and thin
Color options
- Clear film
Functions
- Prevention of nausea and vomiting associated with cancer chemotherapy
- Prevention and treatment of post-operative nausea and vomiting
- Prevention of radiotherapy-induced nausea and vomiting
Materials
- Onsat base
- Cellulose-based film
Technical specifications
- Active ingredient: Onsat base
- Empirical formula: C18H19N3O
- Molecular weight: 293.3
- Dissolves within 20 seconds when placed on the tongue
Design elements
- Oral soluble film
- Packaged in individual pouches
Usability features
- Does not require water for dissolution or swallowing
- Convenient for patients who have difficulty swallowing tablets or capsules
Dosage
- 8 mg and 4 mg tablets or orodispersible tablets
- Injections available
- Dosage varies for different age groups and indications
Administration
- Oral administration
- Film is placed on the tongue and allowed to dissolve
Interaction
- Metabolized by hepatic cytochrome P-450 drug-metabolizing enzymes
- Potential for drug interactions with inducers or inhibitors of these enzymes
Contraindications
- Hypersensitivity to the drug or any of its components
- Concomitant use of apomorphine
Side effects
- Common adverse events: Headache, constipation, diarrhea, rash
- Rare adverse events: Anaphylaxis, brochospasm, tachycardia, hypokalemia
- No evidence of extrapyramidal reactions
Pregnancy and lactation
- No evidence of carcinogenic effects or mutagenicity
- Caution when administered to nursing women
Precautions and warnings
- Patients who have exhibited hypersensitivity to other selective 5-HT3 receptor antagonists may experience hypersensitivity reactions
- Not to be used instead of nasogastric suction
- May mask a progressive ileus and/or gastric distension
Special populations
- Same dosage recommendation for patients with impaired renal function
- Recommended single daily dose for patients with severe hepatic impairment
Therapeutic class
- Anti-emetic drugs
Storage conditions
- Store at temperature not exceeding 30°C in a dry place
- Protect from light and moisture