Osetron 8 mg/4 ml (IM/IV Injection)

4 ml ampoule: ৳ 32.00 (1 x 5: ৳ 160.00)

Medicine Details

Category Details
Generic Ondansetron
Company Aci limited
Also available as
Osetron 8 mg tablet Osetron 4 mg oral solution

Indications

  • Prevention of nausea and vomiting associated with initial and repeat courses of emetogenic cancer chemotherapy
  • Prevention and treatment of post-operative nausea and vomiting
  • Prevention of radiotherapy-induced nausea and vomiting

Description

  • Orally dissolving film designed to be applied on top of the tongue
  • Dissolves within 20 seconds
  • Does not require water for dissolution or swallowing
  • Active ingredient: Ondansetron base
  • Molecular weight: 293.3

Pharmacology

  • Serotonin subtype 3 (5HT3) receptor-antagonist
  • Blocks 5HT3 receptors in the peripheral and central nervous system
  • Mechanisms of action in post-operative nausea and vomiting are not known

Dosage

  • Various dosages for adults, pediatric patients, adults/gertiatric/child of 12 years or over, pediatric (4-11 years)
  • Dosage adjustment for different chemotherapeutic agents and radiotherapy

Administration

  • Tear the pouch carefully
  • Place the film on top of the tongue
  • Do not chew or swallow the film whole
  • Swallow after the film dissolves
  • Wash hands after taking the film

Interaction

  • Osetron does not induce or inhibit the cytochrome P-450 drug-metabolizing enzyme system of the liver
  • Metabolized by hepatic cytochrome P-450 drug-metabolizing enzymes

Contraindications

  • Hypersensitivity to the drug or any of its components
  • Concomitant use of apomorphine

Side Effects

  • Frequently reported adverse events: headache, constipation, diarrhea, rash
  • Other reported adverse events: sensation of flushing or warmth, hiccups, liver enzyme abnormalities, anaphylaxis, brochospasm, tachycardia, angina, hypokalemia, shortness of breath
  • No evidence of extrapyramidal reactions

Pregnancy & Lactation

  • No evidence of carcinogenic effects in rats and mice
  • Not mutagenic in standard tests
  • No impairment of fertility or harm to the fetus in rats and rabbits
  • Caution advised for nursing women

Precautions & Warnings

  • Hypersensitivity reactions reported in patients hypersensitive to other selective 5-HT3 receptor antagonists
  • Not a drug that stimulates gastric or intestinal peristalsis
  • Caution in patients following abdominal surgery or with chemotherapy-induced nausea and vomiting

Use in Special Populations

  • Dosage adjustment for patients with impaired renal function
  • Dosage adjustment for patients with impaired hepatic function
  • Limited information for pediatric patients 4 years of age or younger

Therapeutic Class

  • Anti-emetic drugs

Storage Conditions

  • Store at temperature not exceeding 30°C
  • Dry place
  • Protect from light and moisture

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