Periset 4 mg/5 ml (Oral Solution)
50 ml bottle: ৳ 45.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Ondansetron |
| Company | Acme laboratories ltd |
| Also available as |
Indications
- Prevention of nausea and vomiting associated with initial and repeat courses of emetogenic cancer chemotherapy
- Prevention and treatment of post-operative nausea and vomiting
- Prevention of radiotherapy-induced nausea and vomiting
Description
- Orally dissolving film
- Applied on top of the tongue
- Dissolves within 20 seconds
- Active ingredient: Periset base
- Selective blocking agent of serotonin 5-HT3 receptor
- Empirical formula: C18H19N3O
- Molecular weight: 293.3
Pharmacology
- Potent and highly selective 5HT3 receptor-antagonist
- Mode of action in controlling nausea and vomiting not fully known
- Blocks initiation of vomiting reflex
- Antagonism of 5HT3 receptors in peripheral and central nervous system
Dosage
- Dosage varies for different conditions and age groups
- Includes oral tablets, orodispersible tablets, and injection options
- Specific doses based on body weight and type of treatment
Administration
- Simple 5-step administration process for oral soluble film
- No water required for dissolution or swallowing
Interaction
- Metabolized by hepatic cytochrome P-450 drug-metabolizing enzymes
- Effects of inducers or inhibitors of these enzymes on clearance and half-life
Contraindications
- Hypersensitivity to the drug or its components
- Concomitant use of apomorphine
Side Effects
- Frequently reported adverse events: headache, constipation, diarrhea
- Occasional occurrence of rash, sensation of flushing or warmth, hiccups, liver enzyme abnormalities
- Rare cases of anaphylaxis, brochospasm, tachycardia, angina, hypokalemia, shortness of breath
Pregnancy & Lactation
- No evidence of carcinogenic effects in animal studies
- Not mutagenic in standard tests for mutagenicity
- Excretion in breast milk of rats
- Caution advised for nursing women
Precautions & Warnings
- Reported hypersensitivity reactions in certain patients
- Not a drug that stimulates gastric or intestinal peristalsis
- Caution advised in patients following abdominal surgery
Use in Special Populations
- Dosage adjustment for patients with impaired renal function and hepatic function
- Limited information available for patients 4 years of age or younger
Therapeutic Class
- Anti-emetic drugs
Storage Conditions
- Store at temperature not exceeding 30°C
- Protect from light and moisture