Zofra ODT 4 mg (Dispersible Tablet)
Unit Price: ৳ 5.00 (3 x 10: ৳ 150.00)
Strip Price: ৳ 50.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Ondansetron |
| Company | Eskayef pharmaceuticals ltd |
| Also available as |
Indications
- Prevention of nausea and vomiting associated with initial and repeat courses of emetogenic cancer chemotherapy
- Prevention and treatment of post-operative nausea and vomiting
- Prevention of radiotherapy-induced nausea and vomiting
Description
- Orally dissolving film designed to be applied on top of the tongue
- Dissolves within 20 seconds
- Active ingredient is Zofra ODT base, a selective blocking agent of the serotonin 5-HT3 receptor type
- Empirical formula is C18H19N3O representing a molecular weight of 293.3
Pharmacology
- Potent, highly selective 5HT3 receptor-antagonist
- Exact mode of action in control of nausea and vomiting is not known
- Blocks initiation of vomiting reflex by activating vagal afferents via 5HT3 receptors
Dosage
- Adult dosage for chemotherapy-induced Nausea and Vomiting
- Dosage for Radiotherapy-Induced Nausea and Vomiting
- Dosage for Postoperative Nausea and Vomiting
- Specific dosage instructions for highly emetogenic cancer chemotherapy and moderate emetogenic cancer chemotherapy
- Dosage in pediatric patients
Administration
- Steps for administration of Oral Soluble Film
- Instructions on how to take Onsaf oral soluble film
Interaction
- Zofra ODT does not itself appear to induce or inhibit the cytochrome P-450 drug-metabolizing enzyme system of the liver
- Metabolized by hepatic cytochrome P-450 drug-metabolizing enzymes
Contraindications
- Contraindicated in patients known to have hypersensitivity to the drug or any of its components
- Concomitant use of apomorphine
Side Effects
- Frequently reported adverse events
- Occurrence of rash, sensation of flushing or warmth, hiccups, liver enzyme abnormalities
- Rare cases of anaphylaxis, bronchospasm, tachycardia, angina, hypokalemia, shortness of breath
Pregnancy & Lactation
- No evidence of impaired fertility or harm to the fetus in rats and rabbits at certain oral doses
- No adequate and well-controlled studies in pregnant women
- Excreted in the breast milk of rats
- Caution should be exercised when administered to nursing women
Precautions & Warnings
- Hypersensitivity reactions reported in patients with hypersensitivity to other selective 5-HT3 receptor antagonists
- Should not be used instead of nasogastric suction
- May mask a progressive ileus and/or gastric distension
Use in Special Populations
- Dosage adjustment for patients with impaired renal function
- Dosage adjustment for patients with impaired hepatic function
- Little information about dosage in pediatric patients 4 years of age or younger
Therapeutic Class
Anti-emetic drugs
Storage Conditions
Store at temperature not exceeding 30°C in a dry place, protect from light and moisture