Zofra ODT 8 mg (Dispersible Tablet)

Unit Price: ৳ 10.00 (3 x 14: ৳ 420.00)
Strip Price: ৳ 140.00

Medicine Details

Category Details
Generic Ondansetron
Company Eskayef pharmaceuticals ltd
Also available as
Zofra odt 4 mg tablet Zofra 4 mg oral solution Zofra 8 mg injection

Therapeutic Class

  • Anti-emetic drugs

Indications

  • Prevention of nausea and vomiting associated with initial and repeat courses of emetogenic cancer chemotherapy
  • Prevention and treatment of post-operative nausea and vomiting
  • Prevention of radiotherapy-induced nausea and vomiting

Description

  • Zofra ODT oral soluble film
  • Orally dissolving film
  • Applied on top of the tongue
  • Dissolves within 20 seconds
  • Swallowed with saliva
  • Does not require water for dissolution or swallowing
  • Active ingredient: Zofra ODT base (the racemic form of Zofra ODT)

Mode of Action

  • Potent, highly selective 5HT3 receptor-antagonist
  • Precise mode of action not fully known
  • Blocks initiation of vomiting reflex

Dosage

  • Adult dosage for chemotherapy-induced nausea and vomiting
  • Pediatric dosage for chemotherapy-induced nausea and vomiting
  • Adult dosage for radiotherapy-induced nausea and vomiting
  • Pediatric dosage for radiotherapy-induced nausea and vomiting
  • Dosage for postoperative nausea and vomiting
  • Dosage for different types of cancer chemotherapy
  • Pediatric dosage for different age groups

Administration

  • Steps for administering Oral Soluble Film
  • No requirement for water during administration

Interaction

  • Metabolized by hepatic cytochrome P-450 drug-metabolizing enzymes
  • Potential for clearance and half-life alteration if used with enzyme inducers or inhibitors

Contraindications

  • Hypersensitivity to the drug or any of its components
  • Concomitant use of apomorphine

Side Effects

  • Frequently reported adverse events
  • Mild or moderate adverse events
  • Occurrence of rash, sensation of flushing, hiccups, and liver enzyme abnormalities
  • Rare cases of anaphylaxis, brochospasm, tachycardia, angina, hypokalemia, shortness of breath

Pregnancy & Lactation

  • No evidence of carcinogenic effects in animal studies
  • Not mutagenic in standard tests
  • No effect on fertility or general reproduction performance in rats
  • No adequate and well-controlled studies in pregnant women
  • Excreted in the breast milk of rats

Precautions & Warnings

  • Reported hypersensitivity reactions
  • Not a drug that stimulates gastric or intestinal peristalsis
  • Caution in postoperative and chemotherapy-induced nausea and vomiting

Use in Special Populations

  • Dosage adjustment for patients with impaired renal function
  • Dosage adjustment for patients with impaired hepatic function
  • Limited information about dosage for pediatric patients 4 years of age or younger

Storage Conditions

  • Store at temperatures not exceeding 30°C
  • Dry place
  • Protection from light and moisture

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