Paloron 0.075 mg/1.5 ml (IV Injection)
1.5 ml ampoule: ৳ 75.00 (1 x 4: ৳ 300.00)
Medicine Details
| Category | Details |
|---|---|
| Generic | Palonosetron |
| Company | Ziska pharmaceuticals ltd |
| Also available as |
Indications
- Acute and delayed nausea and vomiting
- Uncontrolled nausea and vomiting
- Chemotherapy-induced nausea and vomiting (CINV)
- Radiotherapy-induced nausea and vomiting (RINV)
- Post-operative & Post-discharge nausea and vomiting (PONV & PDNV)
Pharmacology
- 5-HT3 receptor antagonist
- Strong binding affinity for 5-HT3 receptor
- Little or no affinity for other receptors
- Influence on chemotherapeutic agents
- Influence on postoperative nausea and vomiting
- Linear dose-proportional pharmacokinetics
- Volume of distribution
- Metabolism and excretion
- Plasma protein binding
- Half-life
- Selective participation in the emetic response
Dosage & Administration
- Usual adult tablet dosage: 0.5 mg daily
- Adult IV dosage: 0.075 mg over 10 seconds
- Administered prior to chemotherapy or radiotherapy
- IV dosage for post-operative nausea and vomiting
- Children dosage based on body weight
Interaction
- Safety with corticosteroids, analgesics, and antiemetics
- Non-inhibition of antitumor activity
- Study of pharmacokinetic interactions with metoclopramide
- Inhibition and induction of drug-metabolizing enzymes
Contraindications
- Hypersensitivity to the drug or its components
Side Effects
- Headaches
- Constipation
Pregnancy & Lactation
- Pregnancy category 'B'
- Unknown excretion in breast milk
Use in Special Populations
- No dosage adjustment for elderly patients
- Recommended dosage for children
- No dosage adjustment for patients with renal and hepatic dysfunction
Overdose Effects
- No known antidote
- Supportive care management
Therapeutic Class
- Anti-emetic drugs
Storage Conditions
- Cool and dry place
- Protected from light