Paloron 0.25 mg/5 ml (IV Injection)
5 ml ampoule: ৳ 100.00 (1 x 4: ৳ 400.00)
Medicine Details
| Category | Details |
|---|---|
| Generic | Palonosetron |
| Company | Ziska pharmaceuticals ltd |
| Also available as |
Title and Categories
- Paloron - Anti-emetic drug
Indications
- Acute and delayed nausea and vomiting
- Uncontrolled nausea and vomiting
- Chemotherapy-induced nausea and vomiting (CINV)
- Radiotherapy-induced nausea and vomiting (RINV)
- Post-operative & Post-discharge nausea and vomiting (PONV & PDNV)
Mode of Action
- 5-HT3 receptor antagonist
- Strong binding affinity for 5-HT3 receptor
- Little or no affinity for other receptors
- Blocks the actions of serotonin at 5-HT3 receptor
- Influence on postoperative nausea and vomiting
Pharmacokinetics
- Exhibits linear dose-proportional pharmacokinetics
- Metabolized via kidney and liver
- Longer half-life of 40 hours
- Greater 5-HT3 receptor binding affinity
Dosage and Administration
- Usual adult tablet dosage of 0.5 mg daily
- Single IV dose of 0.075 mg over 10 seconds for adults
- Different dosages for chemotherapy-induced nausea and vomiting, radiotherapy-induced nausea and vomiting, post-operative nausea and vomiting, and children dosage based on body weight
Interactions
- Safe administration with corticosteroids, analgesics, antiemetics/antinauseants, antispasmodics, and anticholinergic agents
- No significant pharmacokinetic interactions with metoclopramide
- Low potential for clinically significant drug interactions
Contraindications
- Contraindicated in patients with hypersensitivity to the drug or any of its components
Side Effects
- Most common adverse reactions are headaches and constipation
Pregnancy and Lactation
- Pregnancy category B
- Not known whether excreted in breast milk
Use in Special Populations
- No dosage adjustment recommended in elderly patients >65 years of age
- Specific dosage for use in children based on age and body weight
- No dosage adjustment recommended in patients with renal and hepatic dysfunction
Overdose Effects
- No known antidote to Paloron
- Overdose should be managed with supportive care
Therapeutic Class
- Anti-emetic drugs
Storage Conditions
- Store in a cool & dry place, protected from light